Aneuploidy Rates in Advanced Maternal Age Patients Supplemented With Coenzyme Q10 (CoQ10) Versus Those That Are Not: a Pilot Study
| Status: | Completed |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 36 - 42 |
| Updated: | 5/6/2018 |
| Start Date: | April 2014 |
| End Date: | May 2018 |
Blastocyst Aneuploidy Rates From Advanced Maternal Age Patients Supplemented With Coenzyme Q10 (CoQ10) Versus Those That Are Not: a Pilot Study
Pregnancy rates for women over 35 years old are significantly lower when compared to younger
women. One of the causes for this decrease is believed to be chromosomal aneuploidy.
Chromosomal aneuploidy is a natural phenomena and occurs in women of every age and has been
implicated in spontaneous miscarriages, and preimplantation embryo wastage (Hassold and Hunt,
2001).
As maternal age increases, so too does the incidence of chromosomal aneuploidy. Embryo
quality from older patients undergoing IVF tends to be reduced and associated with higher
rates of chromosomal abnormalities when compared to good quality embryos (Munne et al.,
1995).
Chromosomal aneuploidy derives from the improper segregation of chromosomes during
preimplantation development. The process of segregation, or mitosis, includes synthesis of
the complete genome, equal division of chromosomes to opposite poles by the spindle
apparatus, and separation of the two cells by cytokinesis, yielding two chromosomally
identical cells. The entire process of cellular and genetic replication requires energy in
the form of adenosine tri phosphate (ATP). ATP is mainly produced in mitochondria in the
process known as the electron transport chain (ETC). There are many important molecules
required for ATP production, CoQ10 can act as the appropriate carrier of electrons through
the ETC. When a deficiency in CoQ10 is present, ATP production is decreased resulting in
aneuploidy (Bentov et al., 2013). Similarly, research has shown that chromosome alignment and
spindle formation are affected by mtDNA copy number (Ge et al., 2012). It has also been shown
that the transfer of ooplasm from young, healthy oocyte donors into oocytes of women with
repeated embryonic failure has result in children with subsequent mitochondrial heteroplasmy
(Cohen et al., 1998).
CoQ10 concentrations have been shown to decrease as age increases (Bentov et al., 2011).
Consequently, the decrease in CoQ10 concentrations seen in older women may cause an increase
in chromosomal aneuploidy in subsequent embryos (Bentov et al., 2013). In this pilot study,
we test the hypothesis that the supplementation of CoQ10 prior to an IVF cycle can increase
mitochondrial DNA activity and possibly decrease chromosomal aneuploidy in AMA patients.
women. One of the causes for this decrease is believed to be chromosomal aneuploidy.
Chromosomal aneuploidy is a natural phenomena and occurs in women of every age and has been
implicated in spontaneous miscarriages, and preimplantation embryo wastage (Hassold and Hunt,
2001).
As maternal age increases, so too does the incidence of chromosomal aneuploidy. Embryo
quality from older patients undergoing IVF tends to be reduced and associated with higher
rates of chromosomal abnormalities when compared to good quality embryos (Munne et al.,
1995).
Chromosomal aneuploidy derives from the improper segregation of chromosomes during
preimplantation development. The process of segregation, or mitosis, includes synthesis of
the complete genome, equal division of chromosomes to opposite poles by the spindle
apparatus, and separation of the two cells by cytokinesis, yielding two chromosomally
identical cells. The entire process of cellular and genetic replication requires energy in
the form of adenosine tri phosphate (ATP). ATP is mainly produced in mitochondria in the
process known as the electron transport chain (ETC). There are many important molecules
required for ATP production, CoQ10 can act as the appropriate carrier of electrons through
the ETC. When a deficiency in CoQ10 is present, ATP production is decreased resulting in
aneuploidy (Bentov et al., 2013). Similarly, research has shown that chromosome alignment and
spindle formation are affected by mtDNA copy number (Ge et al., 2012). It has also been shown
that the transfer of ooplasm from young, healthy oocyte donors into oocytes of women with
repeated embryonic failure has result in children with subsequent mitochondrial heteroplasmy
(Cohen et al., 1998).
CoQ10 concentrations have been shown to decrease as age increases (Bentov et al., 2011).
Consequently, the decrease in CoQ10 concentrations seen in older women may cause an increase
in chromosomal aneuploidy in subsequent embryos (Bentov et al., 2013). In this pilot study,
we test the hypothesis that the supplementation of CoQ10 prior to an IVF cycle can increase
mitochondrial DNA activity and possibly decrease chromosomal aneuploidy in AMA patients.
Brief Summary
Inclusion Criteria:
1. 36-42 years old
2. Must present with an AMH level ≤2.0 ng/mL
3. 1st cycle of IVF treatment
4. Antral follicle count >5 and <20
Exclusion Criteria:
1. BMI >39
2. Active smoker
3. Blood serum baseline level of CoQ10 ≥2.20 µg/mL
4. Prior use of CoQ10
5. Type II diabetes mellitus
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