Carvedilol PAH A Pilot Study of Efficacy and Safety

This is a prospective, open label, uncontrolled, pilot study examining the safety and
efficacy of beta-blocker therapy with carvedilol on RV function in stable PAH Patients with
World Health Organization (WHO) functional class II or III symptoms and RV ejection fraction
(EF) < 40%. Twenty-five evaluable patients will be enrolled at the University of Minnesota.

Specific Aims:

1.1 Primary Efficacy Endpoint: Adult males and females on a stable dose of an approved PAH
medication will undergo cardiac magnetic resonance imaging (MRI), right heart catheterization
(RHC), echocardiogram, 6-minute walk test (6-MWT), measurement of plasma NT-ProBNP and serum
catecholamine, and quality of life assessment. Patients will receive carvedilol (3.25 mg/kg
bid escalating to 25 mg/kg bid over 3 months). Testing is repeated at the end of the study
(month 6). RVEF measured by cardiac MRI is the primary efficacy endpoint. We define a 5%
increase in RVEF as a meaningful change.

Inclusion Criteria:

1. Subjects will be eligible to participate in the study if all of the following
conditions exist:

2. Age > 18 years

3. WHO category 1 pulmonary arterial hypertension (Dana Point 2008)

4. WHO functional class II-III

5. RVEF by cardiac MRI < 40%

6. Mean pulmonary artery pressure > 40 mm Hg

7. Stable on PAH-specific therapy as defined by no change in PAH-specific treatment and
functional class in the past 3 months. Patient can be on either mono or combination
PAH-specific therapy

Exclusion Criteria:

- 1. Subjects will be excluded from participation in the study if any of the following
conditions exist: 2. Significant persistent bradycardia (resting heart rate < 60 bpm)
without a permanent pacemaker 3. Second or third degree AV block without a permanent
pacemaker 4. Significant sinus tachycardia (resting heart rate > 100 bpm) 5. Use of
anti-arrhythmic drugs 6. Hypotension defined as systolic blood pressure < 100 mmHg at
the time of enrollment 7. Significant illness in the past 30 days requiring
hospitalization 8. Acute decompensated right heart failure within past 30 days 9.
Known allergy or intolerance to carvedilol or other β blockers 10. Cardiac index < 2
l/min/m2 or right atrial pressure > 15 mm Hg 11. Asthma