Cardiovascular, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Hospital, Hospital, Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | 30 - 64 |
| Updated: | 3/11/2017 |
| Start Date: | July 2013 |
| End Date: | March 2017 |
Cardiovascular, Cerebrovascular, and Cognitive Function in SCI
Increased life expectancy in individuals with spinal cord injury (SCI) present clinicians
with the challenge of managing the secondary complications of SCI with the chronic diseases
common in an aging population. Cardiovascular disease, cerebral vascular disease, and
cognitive dysfunction are among the primary challenges facing clinicians in the treatment of
an aging population. Cognitive dysfunction has been reported in upwards of 60% of the SCI
population, which have been primarily attributed to concomitant traumatic brain injury or
pre-morbid conditions. Identifying possible modifiable risk factors which contribute to the
increased prevalence of cognitive dysfunction in the SCI population is of significant
clinical relevance and cardiovascular and cerebrovascular disorders have emerged as possible
contributors to the cognitive disorders in the general population. These risk factors
include: physical inactivity, chronically low or high blood pressure (BP), reduced blood
flow to the brain, arterial stiffening, and impaired nervous system regulation of the
cardiovascular system. These risk factors are particularly prominent in the SCI population
as they represent a model of profound inactivity, have trouble regulating blood pressure,
and suffer impaired cardiovascular regulation from their injury. In addition, we've recently
reported deficits in blood flow to the brain at rest and during cognitive tests; with
results being further impaired in SCI with chronically low blood pressure. Therefore the
goals of this project are to determine the influence of cardiovascular and cerebral vascular
responses at rest and during cognitive testing on test performance in 80 individuals with
SCI compared to 50 age-matched non-SCI controls. All potential subjects will undergo a
rigorous two-part screening process which consists of an initial screening via telephone and
a detailed, in-person screening. Eligible subjects will be invited to participate in a 3
hour laboratory visit during which their arterial stiffness, blood pressure, heart rate,
respiration rate and, blood flow to the brain will be monitored at rest and during a
comprehensive series of cognitive tests.
We hypothesize that blood pressure and cerebrovascular response to testing will account
significantly for performance in cognitive testing that otherwise would have been
attributable to SCI status.
with the challenge of managing the secondary complications of SCI with the chronic diseases
common in an aging population. Cardiovascular disease, cerebral vascular disease, and
cognitive dysfunction are among the primary challenges facing clinicians in the treatment of
an aging population. Cognitive dysfunction has been reported in upwards of 60% of the SCI
population, which have been primarily attributed to concomitant traumatic brain injury or
pre-morbid conditions. Identifying possible modifiable risk factors which contribute to the
increased prevalence of cognitive dysfunction in the SCI population is of significant
clinical relevance and cardiovascular and cerebrovascular disorders have emerged as possible
contributors to the cognitive disorders in the general population. These risk factors
include: physical inactivity, chronically low or high blood pressure (BP), reduced blood
flow to the brain, arterial stiffening, and impaired nervous system regulation of the
cardiovascular system. These risk factors are particularly prominent in the SCI population
as they represent a model of profound inactivity, have trouble regulating blood pressure,
and suffer impaired cardiovascular regulation from their injury. In addition, we've recently
reported deficits in blood flow to the brain at rest and during cognitive tests; with
results being further impaired in SCI with chronically low blood pressure. Therefore the
goals of this project are to determine the influence of cardiovascular and cerebral vascular
responses at rest and during cognitive testing on test performance in 80 individuals with
SCI compared to 50 age-matched non-SCI controls. All potential subjects will undergo a
rigorous two-part screening process which consists of an initial screening via telephone and
a detailed, in-person screening. Eligible subjects will be invited to participate in a 3
hour laboratory visit during which their arterial stiffness, blood pressure, heart rate,
respiration rate and, blood flow to the brain will be monitored at rest and during a
comprehensive series of cognitive tests.
We hypothesize that blood pressure and cerebrovascular response to testing will account
significantly for performance in cognitive testing that otherwise would have been
attributable to SCI status.
The cognitive test battery will consists of the tests listed below, administered in the
order given. Each test will be scored according to the
1. California Verbal Learning Test (Total & SD?)
2. Controlled oral word association test
3. Symbol Digit Modalities Test (Oral version)
4. Trail Making Test (Oral version)
5. Stroop Test (W?, C?, CW?)
6. Digit Span (Forwards, Backwards, and Sequencing)
7. California Verbal Learning Test (LD? & Recognition?)
8. Letter-Number Sequencing
9. California Verbal Learning Test (LD Forced recognition?)
10. WASI-II Sub-tests (Vocabulary, Similarities, and Matrix Reasoning)
order given. Each test will be scored according to the
1. California Verbal Learning Test (Total & SD?)
2. Controlled oral word association test
3. Symbol Digit Modalities Test (Oral version)
4. Trail Making Test (Oral version)
5. Stroop Test (W?, C?, CW?)
6. Digit Span (Forwards, Backwards, and Sequencing)
7. California Verbal Learning Test (LD? & Recognition?)
8. Letter-Number Sequencing
9. California Verbal Learning Test (LD Forced recognition?)
10. WASI-II Sub-tests (Vocabulary, Similarities, and Matrix Reasoning)
Inclusion Criteria:
- Between the ages of 30 and 64 years old
- If SCI, the duration of injury must be greater than 1 year
- At least 20/60 minimum acuity in worst eye on the Snell Eye Exam
- A score ≥22 on the Montreal Cognitive Assessment
- English literate
- Able to provide informed consent
Exclusion Criteria:
- Acute illness or infection
- Documented history of:
- Stroke
- Recent illicit drug abuse (from medical chart, within the past 6-months)
- Unstable or uncontrolled seizures
- Neurodegenerative disease including Alzheimer's disease, Parkinson's disease,
Huntington's disease
- Severe TBI (identified by TBI screening tool)
- Any significant history of neurological disease/disorders:
- Alzheimer's disease
- Parkinson's disease
- Vascular dementia
- Huntington's disease
- Pick's disease
- Lewy Body Dementia
- Frontotemporal dementia
- Normal pressure hydrocephalus
- Brain tumor
- Progressive supranuclear palsy
- Seizure disorder
- Multiple sclerosis
- Any significant systemic illness or unstable medical condition, including:
- Uncontrolled diabetes mellitus,
- Uncorrected hypothyroidism or hyperthyroidism,
- Systemic cancer.
- History of schizophrenia or bipolar disorder or any active psychosis
- Alcohol or substance abuse or dependence within the past 6 months (from medical
record)
We found this trial at
1
site
Bronx, New York 10468
Principal Investigator: Jill M Wecht, Ed.D.
Phone: 7185849000
Click here to add this to my saved trials
