Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers

Inclusion Criteria:

1. Diabetes mellitus.

2. Male or female at least 18 years old.

3. Subject must agree to adhere to all protocol procedures and return for all scheduled
visits, and must be willing and able to provide written informed consent.

4. Subject is to be treated on an outpatient basis.

5. Full thickness ulcer or a partial thickness ulcer on the foot distal to the malleoli
with a surface area ≥ 1 cm2 after the wound has undergone appropriate debridement.

6. Localized mild infection of the ulcer.

7. The diagnosis of mild infection must be confirmed immediately following debridement
at Baseline.

8. Subject must have plain radiographs taken within 2 days prior to entry showing no
evidence of bony abnormalities consistent with osteomyelitis, or gas compatible with
tissue crepitus, in the affected foot.

Exclusion Criteria:

1. IDSA-defined moderate infection, including cellulitis extending > 2 cm; lymphangitis;
spread beneath the fascia; deep tissue abscess; gangrene; muscle, joint, or bone
involvement.

2. IDSA-defined severe infection, including systemic toxicity or metabolic instability.

3. Infected diabetic foot ulcer that is associated with local wound complications such
as prosthetic materials or protruding surgical hardware.

4. > 1 infected foot ulcer.

5. Subject is currently receiving topical antimicrobial treatment for a localized
infection of the study ulcer and whose infection is improving in response to
treatment.

6. Subject has received a systemic antibiotic within 48 hours prior to Screening.

7. Concurrent or expected to require systemic antimicrobials during the study period for
any infection, including diabetic foot ulcer.

8. Bone or joint involvement is suspected based on clinical examination or plain X-ray.

9. Clinically significant peripheral arterial disease requiring vascular intervention.

10. Subject is expected to be unable to care for the ulcer or return for all scheduled
visits because of hospitalization, vacation, disability, etc. during the study
period, or is unable to safely monitor the infection status at home.