Brain Connectivity in Age-Related Macular Degeneration
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 50 - 90 |
| Updated: | 2/9/2019 |
| Start Date: | April 2014 |
| End Date: | June 2018 |
Cognitive Changes and Brain Connectivity in Age-Related Macular Degeneration
This study is to determine how cognitive deficits (e.g.,verbal fluency deficit) in patients
with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function.
The study team will assess whether the "brain signatures" associated with specific cognitive
deficits differ in older adults with and without AMD.
with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function.
The study team will assess whether the "brain signatures" associated with specific cognitive
deficits differ in older adults with and without AMD.
Inclusion Criteria:
AMD
- Vision loss attributable to AMD
Controls
- Age match (± 5 yrs)
- Gender match
- Education match (± 4yrs)
- Normal macular exam
Exclusion Criteria:
AMD
- Other significant eye pathology
- Mod/severe dementia
- Communication barrier that precludes testing
Controls
- Other significant eye pathology
- Mod/severe dementia
- Communication barrier that precludes testing
MRI subset
- Devices or material incompatible with 3.0 Tesla MRI
- Conditions that may interfere with interpretation of fMRI (e.g. history of stroke,
brain tumor or previous brain surgery; psychoactive medications; seizure disorder)
- Claustrophobia
- Left-handed
- Body weight > 300 lbs
- Pregnant women
We found this trial at
1
site
2301 Erwin Rd
Durham, North Carolina 27710
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Heather Whitson, MD
Phone: 919-660-7514
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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