Atomoxetine's Effects On Nicotine Response And Stress Response In Smokers

Inclusion Criteria:

- female and male smokers, not treatment seeking, aged 18 to 55 years;

- history of smoking daily for the past 12 months, at least 5 cigarettes daily;

- CO level > 10ppm;

- for women: not pregnant as determined by pregnancy screening, nor breast feeding, and
using acceptable birth control methods.

Exclusion Criteria:

- history of major medical illnesses including asthma or chronic obstructive lung
disease, history or current gastrointestinal ulcer, hepatic or renal impairment,
coronary artery disease, cardiac rhythm disturbances or other medical conditions that
the study physician deems contraindicated for the subject to be in the study;

- regular use of psychotropic medication (antidepressants, antipsychotics, or
anxiolytics)

- recent psychiatric diagnosis and treatment for Axis I disorders including major
depression, bipolar affective disorder, schizophrenia and panic disorder within the
past year. We will make an exception for the following Axis I diagnoses: nicotine
dependence and alcohol or other drug dependence (i.e., cocaine, opioid) as long as
they are not meeting abuse or dependence criteria within the past 3 months for
alcohol or drug use;

- use of drugs that slow heart rate (eg, beta-blockers), which may increase the risk of
bradycardia and AV block, or NSAIDs, which may increase potential for developing
ulcers/active or occult gastrointestinal bleeding;

- known allergy to atomoxetine