Computerized Cognition Testing in Participants With Mild Alzheimer's Disease (AD) Treated With Donepezil (MK-0000-318)

Inclusion Criteria:

- Meets listed criteria for a diagnosis of probable AD

- Has a clearly documented history either in medical records or from an informant of
cognitive decline over at least 6 months

- Has a reliable partner/caregiver who is willing to provide input by participating in
assessments

- Has results of a physical examination and clinical laboratory tests within normal or
clinically acceptable limits

- Can communicate with trial staff acceptably, possesses the ability to respond
verbally to questions, follow instructions, complete questionnaires, and adhere to
visit schedules

- Can read at a 9th grade level or equivalent, and has an acceptable history of
academic achievement and/or employment

- Has a magnetic resonance imaging (MRI) scan that rules out non-AD conditions
contributing to cognitive dysfunction

- Capably performs the CogState screening battery

- Has adequate visual acuity and function

- Females are not of childbearing potential

Exclusion Criteria:

- Has ever received acetylcholinesterase inhibitors, memantine, or other symptomatic AD
treatment including approved medical foods

- Has an uncontrolled, clinically significant medical condition or situation within 3
months prior to screening

- Has had major surgery within 3 months prior to screening

- Has tested positive for human immunodeficiency virus (HIV) or has evidence of an
active hepatitis B infection

- Has a history of malignancy within the prior 5 years

- Is unwilling or ineligible to undergo an MRI scan

- Has a history of clinically important structural changes on screening MRI scan

- Has a clinically important history of stroke or a diagnosis of vascular dementia

- Has evidence of a clinically relevant non-AD neurological disorder

- Has a history of head trauma, or serious infectious disease affecting the brain
within the prior 3-5 years

- Has evidence of a clinically relevant or unstable psychiatric disorder, excepting
major depression in remission

- Has evidence of a current episode of major depression

- Has evidence of Type 4 or Type 5 Suicidal Ideation

- Has clinically significant vitamin B12 or folate deficiency in the 6 months prior to
screening

- Is pregnant, attempting to become pregnant or is nursing children

- Has used any investigational drug or participated in any other clinical trial within
the prior 30 days

- Has a history of alcoholism or drug dependency/abuse within the last 5 years

- Has a relative contraindication to donepezil including sick sinus syndrome, third
degree heart block, active gastrointestinal (GI) bleeding, Zollinger-Ellison
syndrome, uncontrolled peptic ulcer disease, or uncontrolled asthma