Dichotic Listening as a Predictor of Medication Response in Depression
| Status: | Completed |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD), Endocrine |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 5/2/2018 |
| Start Date: | July 2006 |
| End Date: | August 2011 |
This study will recruit 100 depressed patients to test whether the previous finding of an
association between treatment response (with treatment groups including placebo, imipramine,
and fluoxetine) and preferences of hemispheric laterality in perceptual processing are also
found with a different type of commonly used anti-depressant, bupropion.
association between treatment response (with treatment groups including placebo, imipramine,
and fluoxetine) and preferences of hemispheric laterality in perceptual processing are also
found with a different type of commonly used anti-depressant, bupropion.
Preliminary data suggest that depressed patients with increased left hemispheric laterality
of perceptual processing are unlikely to improve during 6 weeks' treatment with placebo,
while being very responsive to either imipramine or fluoxetine. Depressed patients who do not
show evidence of poor right hemispheric functioning respond significantly more often to
placebo than those with poor right hemispheric functioning , and do not show an advantage of
drug over placebo. 100 patients will be tested with verbal and nonverbal dichotic tests, and
then treated sequentially with bupropion, escitalopram, and imipramine. Preferential
hemisphere for auditory processing will be correlated with treatment outcome.
of perceptual processing are unlikely to improve during 6 weeks' treatment with placebo,
while being very responsive to either imipramine or fluoxetine. Depressed patients who do not
show evidence of poor right hemispheric functioning respond significantly more often to
placebo than those with poor right hemispheric functioning , and do not show an advantage of
drug over placebo. 100 patients will be tested with verbal and nonverbal dichotic tests, and
then treated sequentially with bupropion, escitalopram, and imipramine. Preferential
hemisphere for auditory processing will be correlated with treatment outcome.
Inclusion Criteria:
1. Ages between 18-65
2. Meets Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) criteria for current
Major Depression, Dysthymia or Depression Not Otherwise Specified
Exclusion Criteria:
1. Known Hearing impairment
2. Active suicidal ideation (history of suicide attempts will be evaluated on a case by
case basis).
3. Hamilton Rating Scale for Depression (HAMD), 21-item total score >20
4. Current (past 6 months)alcohol and/or drug abuse or dependence
5. Medical condition likely to require intervention contraindicated with study medication
(e.g., known arrhythmia likely to be exacerbated by Imipramine)
6. Bipolar I
7. Psychosis
8. Non-response to adequate trial of study medication (i.e., > or = 4 weeks on > or =
bupropion 300mg/d, escitalopram 30mg/d, or imipramine 200mg/d)
9. Premenopausal women not using known effective birth control
10. Not currently depressed (whether considered due to current treatment or not)
11. History of seizure, seizure disorder, anorexia nervosa, or bulimia
12. Left-handed -
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New York State Psychiatric Institute The New York State Psychiatric Institute (NYSPI), established in 1895,...
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