Grass Observational Study

Inclusion Criteria:

- History of moderate to severe rhinoconjunctivitis consistent with allergy to grass
for at least 2 years.

- Forced Expiratory Volume in 1 Second (FEV1) of at least 70% of predicted value or
personal best if available at the Screening Visit.

- Perennial Rye grass or Timothy grass-specific IgE ≥ 0.35 kU/L as measured by
ImmunoCAP®.

- Positive skin prick test to Perennial Rye grass or Timothy grass allergen

Exclusion Criteria:

- Positive skin prick test ≥ 5 mm to any confounding, co-existing seasonal allergens
likely to be present during the pre-season baseline and grass pollen period.

- Medical records of symptomatic perennial allergic rhinitis and/or asthma or a
positive skin test ≥ 5 mm due to a perennial allergen to which the subject is
regularly exposed (moulds, dust mites, cockroaches, and animal dander) and which
cannot be avoided during the course of the study.

- Previous immunotherapy treatment with any grass allergen for more than 1 month within
5 years prior to screening.

- Subjects who had been treated with any non-grass licensed allergen immunotherapy
extracts or non-grass investigational immunotherapy for more than 1 month within 1
year.