A Study Of PF-06664178 In Patients With Advanced Solid Tumors



Status:Terminated
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:10/14/2017
Start Date:August 2014
End Date:June 2016

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 1, Dose Escalation Study Of PF-06664178 In Patients With Locally Advanced Or Metastatic Solid Tumors

To assess the safety and tolerability at increasing dose levels of PF-06664178 in patients
with advanced solid tumors in order to determine the maximum tolerated dose and select the
recommended Phase 2 dose.


Inclusion Criteria:

- Diagnosis of solid tumor that is advanced/metastatic and resistant to standard therapy
or for whom no standard therapy is available

- Performance Status of 0 or 1

- Adequate bone marrow, kidney and liver function

- Part 2 includes target expressing NSCLC, ovarian or breast cancer patients

Exclusion Criteria:

- Brain metastases requiring steroids

- Major surgery, radiation therapy, or systemic anti-cancer therapy within 4 weeks of
study treatment start (6 weeks for mitomycin C or nitrosoureas)

- Active and clinically significant bacterial, fungal, or viral infection
We found this trial at
10
sites
University of Colorado Denver CTO (CTRC)
Aurora, Colorado 80045
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Aurora, CO
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Seattle Cancer Care Alliance
825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, WA
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Anschutz Cancer Pavilion
Aurora, Colorado 80045
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Aurora, CO
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University of Colorado Hospital
12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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Aurora, CO
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Keck Hospital of USC
Los Angeles, California 90033
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Los Angeles, CA
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Lac & Usc Medical Center
Los Angeles, California 90033
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Los Angeles, CA
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U.S.C./Norris Comprehensive Cancer Center
1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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Los Angeles, CA
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USC/Norris Comprehensive Cancer Center /Investigational Drug Services
Los Angeles, California 90033
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Los Angeles, CA
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Swedish Medical Center
5300 Tallman Ave NW
Seattle, Washington 98122
(206) 782-2700
Swedish Medical Center Since 1910, Swedish has been the region's hallmark for excellence in health...
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Seattle, WA
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University of Washington Medical Center
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
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Seattle, WA
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