A Study of JNJ-56021927 (ARN-509) and Abiraterone Acetate in Participants With Metastatic Castration-Resistant Prostate Cancer

This is a multicenter, open-label (participants will know the identity of study drug
received) study in participants with Metastatic Castration-Resistant Prostate Cancer (mCRPC).
The study is a single sequence design (ie, all participants will take abiraterone acetate +
prednisone [AAP] once daily on Days 1-7 of Treatment Cycle 1 and then proceed with combined
daily intake of AAP+JNJ-56021927 from Treatment Cycle 1, Day 8 through to the end of
treatment [ie, for up to an expected duration of approximately 18 months] and will be
conducted as two cohorts (group of participant's). The study will consist of a 28-day
screening phase to determine eligibility, an open-label treatment phase consisting of 28-day
treatment cycles, and a 30-day follow-up phase for collection of adverse events (AE) after
last dose of study drug. Participants will have blood samples collected during the study to
evaluate pharmacokinetics, safety, and antitumor activity (PSA). Participant safety will also
be monitored by the collection of adverse events. Imaging assessments for disease evaluation
will be planned at discretion of the Investigator. Once all participants have completed study
treatment up to Cycle 3 Day 1, a data cutoff is planned to evaluate the short term safety
profile of the combination and to complete the PK analysis up to the cutoff date. All
participants will continue on study (ie, to receive treatment) until disease progression,
withdrawal of consent, lost to follow-up, or the occurrence of unacceptable toxicity. The end
of the study is defined when all participants have completed treatment. Participant's safety
will be monitored throughout the study.

Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to
(<=) 2

- Histologically or cytologically confirmed adenocarcinoma of the prostate

- Documentation of metastatic disease

- Prostate cancer progression

- Surgically or medically castrated, with testosterone levels of less than (<) 50
nanogram per deciliter (ng/dL)

- Adequate bone marrow and organ function

Exclusion Criteria:

- Known brain metastases

- Pathological finding consistent with small cell carcinoma of the prostate

- Administration of an investigational agent within 4 weeks of Treatment Cycle 1, Day 1

- Chemotherapy, or immunotherapy for the treatment of prostate cancer within 4 weeks of
Treatment Cycle 1, Day 1

- Therapies that must be discontinued or substituted prior to Treatment Cycle 1, Day 1
include the following: Medications known to lower the seizure threshold; Herbal and
non-herbal products that may decrease prostate specific antigen (PSA) levels (that is,
saw palmetto, pomegranates or pomegranate juice); Medications known to induce drug
metabolizing enzymes such as dexamethasone, rifampicin, carbamazepine, phenytoin,
phenobarbital, St. John's wort, etc.; and, potent inhibitors of CYP3A4 or CYP2C8