A Dose Escalation Study of PF-06650808 in Patients With Advanced Solid Tumors



Status:Terminated
Conditions:Breast Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/31/2019
Start Date:June 2014
End Date:July 2017

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A PHASE 1 DOSE ESCALATION STUDY EVALUATING THE SAFETY AND TOLERABILITY OF PF-06650808 IN PATIENTS WITH ADVANCED SOLID TUMORS

To assess the safety and tolerability at increasing dose levels of PF-06650808 in patients
with advanced solid tumors in order to determine the maximum tolerated dose and select the
recommended Phase 2 dose.


Inclusion Criteria:

- Diagnosis of advanced/metastatic solid tumor that is resistant to standard therapy or
for which no standard therapy is available

- Previously treated metastatic triple negative breast cancer that expresses Notch3 with
at least one measurable lesion

- Adequate bone marrow, renal and liver function

Exclusion Criteria:

- Major surgery, radiation therapy or systemic anti-cancer therapy within 4 weeks of
starting study treatment

- Patients with known symptomatic brain metastases requiring steroids

- Prior treatment with a compound of the same mechanism
We found this trial at
11
sites
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Santa Monica, CA
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Columbus, OH
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Columbus, OH
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from
Columbus, OH
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Columbus, OH
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Los Angeles, CA
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Los Angeles, California 90095
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Los Angeles, CA
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Los Angeles, California 90095
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Los Angeles, CA
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Los Angeles, California 90095
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Los Angeles, CA
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from
San Antonio, TX
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Santa Monica, California 90404
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mi
from
Santa Monica, CA
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