Low Glycemic Load Diet in Patients With Stage I-III Colon Cancer

PRIMARY OBJECTIVES:

I. To determine the feasibility of following a low or medium glycemic load diet in patients
with stage I-III (local-regional) colon cancer.

SECONDARY OBJECTIVES:

I. To determine patient-reported acceptability of diet. II. To determine nutritionist
resources utilized. III. To evaluate the effect of lowering dietary glycemic load on body
mass index (BMI), lipid metabolism and pro-oncogenic intermediaries of cellular metabolism.

OUTLINE: Patients are sequentially enrolled in 1 of 4 possible cohorts as needed based on the
feasibility of the prior cohort.

COHORT 1: Patients follow a low glycemic load diet with standard dietary intervention
(contact with nutritionist in person every 2 weeks with phone contact on the alternating
weeks) for 12 weeks.

COHORT 2: Patients follow a low glycemic load diet with intensified dietary intervention
(contact with nutritionist in person every week) for 12 weeks.

COHORT 3: Patients follow a medium glycemic load diet with standard dietary intervention for
12 weeks.

COHORT 4: Patients follow a medium glycemic load diet with intensified dietary intervention
for 12 weeks.

Inclusion Criteria:

- Patients must have stage I-III colon or rectal cancer and have undergone definitive
therapy; definitive therapy may have included surgery alone, or surgery plus
neoadjuvant and/or adjuvant therapy

- Patients must regularly consume a diet with a glycemic load > 150 as estimated through
the 3 day food recall

- Patients must readily be available for a 3 month period and agree to participate in
regular dietary adherence assessments (surveys and phone interviews)

Exclusion Criteria:

- Current participation in an intervention targeting diet or exercise