A Volume, Motion, and Anatomically Adaptive Approach to Photon and Proton Beam Radiotherapy
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Lung Cancer, Lung Cancer, Colorectal Cancer, Colorectal Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/30/2018 |
| Start Date: | September 2010 |
This pilot study will determine changes over time in tumor volume/motion & patient anatomy,
as well as dose distributions to normal organs. The study will inform medical decision-making
about need for (and timing of) re-calibration of radiation dosimetry plans. Weekly CT and/or
serial MR scans will be employed for those patients receiving 7-8 wks of radiation therapy.
The study will enroll 30 patients in each stratum: Non small cell lung cancer (NSCLC), Head &
Neck, gastrointestinal (GI) and Gynecologic tumor.
as well as dose distributions to normal organs. The study will inform medical decision-making
about need for (and timing of) re-calibration of radiation dosimetry plans. Weekly CT and/or
serial MR scans will be employed for those patients receiving 7-8 wks of radiation therapy.
The study will enroll 30 patients in each stratum: Non small cell lung cancer (NSCLC), Head &
Neck, gastrointestinal (GI) and Gynecologic tumor.
Inclusion Criteria:
- Aged 18 and above.
- Biopsy proven diagnosis of non-small cell lung cancer, small cell lung cancer, head
and neck, esophageal, gastric, pancreatic, anal, hepatic, biliary, colorectal,
cervical, endometrial, vaginal, vulvar, ovarian cancer and any other gastrointestinal
or gynecological cancers requiring definitive radiotherapy alone with or without
concurrent chemotherapy.
- Able to provide written informed consent and comply with all study procedures.
- Entire course of radiotherapy will be delivered at the University of Pennsylvania
Perelman Center for Advanced Medicine.
Exclusion Criteria:
- Pregnancy or women of childbearing potential and men who are sexually active and not
willing/able to use medically acceptable forms of contraception; this exclusion is
necessary because the treatment involved in this study may be significantly teratogenic.
We found this trial at
1
site
3400 Civic Center Blvd
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
(215) 662-6065
Abramson Cancer Center of the University of Pennsylvania The Abramson Cancer Center of the University...
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