Phase I of Biologics and Chemoradiation Therapy for Advanced Head and Neck Cancer



Status:Archived
Conditions:Skin Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011

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A Phase I Study of the Combination of Chemoradiotherapy With Biologic Therapy for Advanced Head and Neck Cancer


To determine a safe and effective doses of two biologic drugs, erlotinib and bevacizumab
when used with chemotherapy and radiation therapy in advanced head and neck cancer


Locally advanced non-operative, Stage IV head and neck cancer has at best a guarded
prognosis. Improvements in outcome have been achieved via the combination of chemotherapy
and radiotherapy. Concurrent chemoradiotherapy is needed to optimize results, although
recent data suggest a benefit from induction therapy as well. Nonetheless, despite high
remission rates, most of these patients will suffer local-regional and/or distant recurrence
from their disease.

The proposed study will build upon the framework of chemoradiotherapy (induction plus
concurrent) via the addition of a double biologic therapy. Specifically, the combination of
bevacizumab and erlotinib will be used, as has been studied in other types of cancer.


We found this trial at
1
site
Philadelphia, Pennsylvania 19107
?
mi
from
Philadelphia, PA
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