Phenotypic and Genotypic Markers of Performance Vulnerability to Sleep Loss
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 50 |
| Updated: | 4/21/2016 |
| Start Date: | October 2010 |
| End Date: | November 2015 |
Insufficient sleep is common, affecting 20-40% of adults, and resulting from sleep
disorders, medical conditions, work demands, stress/emotional distress, and social/domestic
responsibilities. It produces significant social, financial and health-related costs, and it
has increasingly become a major public health concern as population studies worldwide have
found that reduced sleep duration is associated with increased risks of obesity, morbidity,
and mortality. It is well established that sleep loss causes fatigue and sleepiness, as well
as errors and accidents that are due to its adverse neurobehavioral effects on alertness,
mood, and cognitive functions. However, there are substantial, trait-like differences among
people in the extent to which they experience such neurobehavioral deficits when sleep
deprived. Common genetic variations involved in sleep-wake, circadian, and cognitive
regulation may underlie these large inter-individual differences in neurobehavioral
vulnerability to sleep deprivation, though it remains unclear whether different types of
sleep deprivation involve the same phenotypic responses and same genotypic contributors.
This project will be the first large-scale investigation of markers of differential
cognitive vulnerability to both acute total sleep loss and chronic partial sleep loss. It
will identify individuals who are at significant risk for fatigue and severe impairments
from sleep loss. A total of 110 healthy adults will undergo a 13-day laboratory protocol to
thoroughly characterize their cognitive, psychological and physiological responses to two of
the most common forms of sleep loss--acute total sleep deprivation (1 night of sleep loss)
and chronic partial sleep deprivation (5 nights of sleep limited to 4 hr). The findings from
this study will represent a critical first step toward tailoring appropriate follow-up
interventions for sleep loss and its symptomatic relief by finding predictors of at-risk
individuals who should avoid sleep loss whenever possible, and/or seek effective
countermeasures. Whether or not markers of neurobehavioral vulnerability to sleep loss are
identified, the results of the project will help inform public policies pertaining to the
need for adequate sleep and for countermeasures for sleep loss, and also will further our
understanding and management of vulnerability to excessive sleepiness due to common sleep
and medical disorders.
disorders, medical conditions, work demands, stress/emotional distress, and social/domestic
responsibilities. It produces significant social, financial and health-related costs, and it
has increasingly become a major public health concern as population studies worldwide have
found that reduced sleep duration is associated with increased risks of obesity, morbidity,
and mortality. It is well established that sleep loss causes fatigue and sleepiness, as well
as errors and accidents that are due to its adverse neurobehavioral effects on alertness,
mood, and cognitive functions. However, there are substantial, trait-like differences among
people in the extent to which they experience such neurobehavioral deficits when sleep
deprived. Common genetic variations involved in sleep-wake, circadian, and cognitive
regulation may underlie these large inter-individual differences in neurobehavioral
vulnerability to sleep deprivation, though it remains unclear whether different types of
sleep deprivation involve the same phenotypic responses and same genotypic contributors.
This project will be the first large-scale investigation of markers of differential
cognitive vulnerability to both acute total sleep loss and chronic partial sleep loss. It
will identify individuals who are at significant risk for fatigue and severe impairments
from sleep loss. A total of 110 healthy adults will undergo a 13-day laboratory protocol to
thoroughly characterize their cognitive, psychological and physiological responses to two of
the most common forms of sleep loss--acute total sleep deprivation (1 night of sleep loss)
and chronic partial sleep deprivation (5 nights of sleep limited to 4 hr). The findings from
this study will represent a critical first step toward tailoring appropriate follow-up
interventions for sleep loss and its symptomatic relief by finding predictors of at-risk
individuals who should avoid sleep loss whenever possible, and/or seek effective
countermeasures. Whether or not markers of neurobehavioral vulnerability to sleep loss are
identified, the results of the project will help inform public policies pertaining to the
need for adequate sleep and for countermeasures for sleep loss, and also will further our
understanding and management of vulnerability to excessive sleepiness due to common sleep
and medical disorders.
Inclusion Criteria:
- A total of N=110 adult subjects (aged 21-50 yr), N=55 females and N=55 males of all
ethnicities, will be randomized to the 2 different experimental conditions. Subjects
must also be comparable in terms of their homeostatic and circadian sleep-wake
regulation parameters. In order to be eligible to participate, subjects must meet the
following inclusion criteria:
1. Age between 21 and 50 years (average age of our current protocols is 31 years)
2. Body mass index (BMI) within 20.5% of normal
3. Stable, normally-timed sleep-wake cycle as determined by interview, 2-week daily
sleep log, and 2-week wrist actigraphic evidence, and defined by:
4. Habitual nocturnal sleep duration between 6.5h and 8.5h
5. Habitual morning awakening between 0600h and 0930h
Exclusion Criteria:
- 1. No evidence of habitual napping 2. No shift work, transmeridian travel or
irregular sleep/wake routine in the past 60 days 3. No sleep disorder, determined by
history, actigraph, pulse oximetry and PSG 4. No history of mania or psychosis 5. No
current depression as determined by the Beck Depression Inventory 6. No alcohol or
drug abuse in the past year based upon history and urine toxicology screen
We found this trial at
1
site
Philadelphia, Pennsylvania 19104
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