A Study Evaluating Pertuzumab (Perjeta) Combined With Trastuzumab (Herceptin) and Standard Anthracycline-based Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Locally Advanced, Inflammatory, or Early-stage Breast Cancer

Inclusion Criteria:

- Male and female participants with locally advanced, inflammatory, or early-stage,
unilateral, and histologically confirmed invasive breast cancer. Participants with
inflammatory breast cancer must be able to have a core needle biopsy

- Primary tumor greater than (>) 2 centimeters (cm) in diameter, or > 5 millimeters (mm)
in diameter and node-positive

- HER2-positive breast cancer confirmed by a central laboratory

- Availability of tumor tissue specimen

- Baseline LVEF greater than or equal to (>/=) 55%

- Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to
(
- At least 4 weeks since major unrelated surgery, with full recovery

- Women of childbearing potential and male participants with partners of childbearing
potential must agree to use a "highly effective" non-hormonal form of contraception or
two "effective" forms of non-hormonal contraception by the patient and/or partner.
Contraception must continue for the duration of study treatment and for at least 7
months after the last dose of study treatment

Exclusion Criteria:

- Metastatic disease (Stage IV) or bilateral breast cancer

- Participants who have had an incisional biopsy of the primary tumor or the primary
tumor excised

- Prior breast or non-breast malignancy within 5 years prior to study entry, except for
carcinoma in situ and basal cell and squamous cell carcinoma of the skin. Participants
with malignancies occurring more than 5 years prior to study entry are permitted if
curatively treated

- Any previous systemic therapy (including chemotherapy, immunotherapy, HER2 targeted
agents, and antitumor vaccines) for cancer, or radiation therapy for cancer

- Participants with a past history of ductal carcinoma in situ (DCIS) or lobular
carcinoma in situ (LCIS) are not allowed to enter the study if they have received any
systemic therapy for its treatment or radiation therapy to the ipsilateral breast
(they are allowed to enter the study if treated with surgery alone)

- High-risk participants who have received chemopreventive drugs in the past are not
allowed to enter the study

- Inadequate bone marrow, renal, or liver function

- History or evidence of cardiovascular condition

- Dyspnea at rest or other diseases that require continuous oxygen therapy

- Severe, uncontrolled systemic disease

- Participants with poorly controlled diabetes or with evidence of clinically
significant diabetic vascular complications

- Pregnancy or breast-feeding women

- Participants who received any investigational treatment within 4 weeks of study start

- Participants with known infection with human immunodeficiency virus (HIV), hepatitis B
virus, or hepatitis C virus

- Current chronic daily treatment with corticosteroids (dose >10 mg methylprednisolone
or equivalent [excluding inhaled steroids])

- Known hypersensitivity to any of the study drugs or excipients