A Pilot Study of Effect of Dexmedetomidine on Sleep and Inflammation in Critically Ill Patients

Over 1 million patients receive mechanical ventilation every year in the United States. In
mechanically ventilated patients, despite sedative infusions, sleep is severely disrupted.
Sleep disruption, in turn, can lead to activation of sympathetic nervous system and elevated
inflammatory cytokines. Both sympathetic hyperactivity and elevated cytokines have been
associated with delirium, which, in turn, is associated with increased mortality and higher
healthcare costs. Currently, however, there is very little understanding of the
inter-relationship between critical illness, sleep, and neuropsychological well-being. The
purpose of this study is to collect preliminary data on the short-term effects of sedation
with and without sympatholysis on sleep and inflammation in critically ill patients
receiving mechanical ventilation. This pilot study will be accomplished by performing sleep
studies and circulating cytokine measurements in critically ill patients randomized to
receive two different sedation strategies: Dexmedetomidine versus Midazolam and Fentanyl.
The ultimate goal of this program of research is to identify sedation practices that are
least associated with adverse short- and long-term consequences, and thereby ultimately help
improve sleep quality and quality of life in patients surviving critical illness.

Inclusion Criteria:

- Patients requiring mechanical ventilation with a diagnosis of

- Acute Respiratory Distress Syndrome

- Cardiogenic Pulmonary Edema

- Pneumonia

- Chronic obstructive pulmonary disease

Exclusion Criteria:

- Patients who are considered too unstable to undergo this investigation by their
primary physician

- Comatose patients, or patients with severe debilitating neurological disease

- Renal insufficiency (Sr. Creatinine > 2 mg/dL)

- Heart block (second or third degree heart block) or sinus bradycardia (heart rate <
60 beats per minute)

- Pregnancy