Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Cardiology, Hospital |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | 18 - 89 |
| Updated: | 4/21/2016 |
| Start Date: | January 2014 |
| End Date: | March 2016 |
| Contact: | Colleen K Dingmann, R.N., Ph.D. |
| Email: | colleen.dingmann@ucdenver.edu |
| Phone: | 303-724-7494 |
The purpose of this study is to conduct a prospective, randomized, controlled trial
comparing a restrictive vs. conservative fluid strategy in thoracic surgery patients.
Excessive perioperative fluid has been retrospectively implicated in the development
postoperative acute lung injury (PALI) and pulmonary edema following lung resection.
However, fluid restriction in these patients is not without risk and may compromise end
organ perfusion (i.e. acute kidney injury). The hypothesis is that a conservative fluid
approach in thoracic surgery patients will result in better end organ perfusion with fewer
occasions of acute kidney injury (AKI) without causing an increase in postoperative acute
lung injury or pulmonary edema.
comparing a restrictive vs. conservative fluid strategy in thoracic surgery patients.
Excessive perioperative fluid has been retrospectively implicated in the development
postoperative acute lung injury (PALI) and pulmonary edema following lung resection.
However, fluid restriction in these patients is not without risk and may compromise end
organ perfusion (i.e. acute kidney injury). The hypothesis is that a conservative fluid
approach in thoracic surgery patients will result in better end organ perfusion with fewer
occasions of acute kidney injury (AKI) without causing an increase in postoperative acute
lung injury or pulmonary edema.
Inclusion Criteria:
- between 18-89 years of age
- undergoing pulmonary lobectomy with open or video assisted thoracotomy
Exclusion Criteria:
- patient refusal
- pregnancy
- cardiac arrhythmia
- pacemaker dependency
- severe aortic insufficiency
- idiopathic hypertrophic subaortic stenosis
- prisoners
- decisionally challenged
- patients that refuse to receive intravenous fluid products made from human plasma
(Albumin 5%)
- patients with skin infection or breakdown on their fingers
- severe peripheral vascular disease
- evidence of compromised finger perfusion will be excluded
We found this trial at
1
site
12605 East 16th Avenue
Aurora, Colorado 80045
Aurora, Colorado 80045
720-848-0000
Phone: 303-724-7494
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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