Echocardiography in Septic Shock
| Status: | Recruiting |
|---|---|
| Conditions: | Hospital, Hospital, Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 13 - Any |
| Updated: | 12/1/2018 |
| Start Date: | October 2008 |
| End Date: | December 2019 |
| Contact: | Kimberly Rhodes |
| Email: | kimberly.rhodes@imail.org |
| Phone: | 801-507-4791 |
ICU Echocardiography in Resuscitation of Sepsis and Septic Shock
BACKGROUND: Echocardiography can provide evaluation of right or left ventricular dysfunction
and volume status during resuscitation of patients with sepsis and septic shock and guide
intravenous vasopressor and fluid therapy. While there are numerous echocardiographic studies
regarding cardiac function and volume status in patients with established shock, there are
none that describe these during the early resuscitation of septic shock.
The study objective is to correlate echocardiographic findings with clinical parameters and
net fluid balance measured during the early resuscitation of critically ill patients with
sepsis and septic shock.
Aim 1) correlate echocardiographic findings of cardiac function with physiologic markers in
the early hours of resuscitation
Aim 2) correlate cardiac function and fluid status with clinical outcomes
Aim 3) evaluate the change in cardiac function over time in patients with sepsis and septic
shock
Aim 4) evaluate long term clinical outcomes for patients with sepsis and septic shock.
and volume status during resuscitation of patients with sepsis and septic shock and guide
intravenous vasopressor and fluid therapy. While there are numerous echocardiographic studies
regarding cardiac function and volume status in patients with established shock, there are
none that describe these during the early resuscitation of septic shock.
The study objective is to correlate echocardiographic findings with clinical parameters and
net fluid balance measured during the early resuscitation of critically ill patients with
sepsis and septic shock.
Aim 1) correlate echocardiographic findings of cardiac function with physiologic markers in
the early hours of resuscitation
Aim 2) correlate cardiac function and fluid status with clinical outcomes
Aim 3) evaluate the change in cardiac function over time in patients with sepsis and septic
shock
Aim 4) evaluate long term clinical outcomes for patients with sepsis and septic shock.
Inclusion Criteria:
- at least 13 years of age
SEPSIS PATIENTS:
Sepsis patients must have
1. Suspected or confirmed infection
AND
2. Organ dysfunction as defined by a SOFA >= 2 above baseline (if no baseline data
available, SOFA assumed to be 0)
OR
SEPTIC SHOCK PATIENTS:
AFTER INFUSION OF 20ML/KG CRYSTALLOID OR EQUIVALENT, Septic shock patients must have
1. Suspected or confirmed infection
AND
2. Lactate > 2 mmol/L
AND
3. Receiving vasopressors
- Enrollment of patients should occur within 8 hours of meeting criteria for severe
sepsis or septic shock if it is required that a research only TTE be performed in
the 0-6 hours after ICU admission. If a clinical TTE is performed in this
timeframe, patients may be enrolled up to 24 hours after ICU admission.
Exclusion Criteria:
We found this trial at
1
site
5121 S Cottonwood St
Murray, Utah 84157
Murray, Utah 84157
(801) 507-7000
Principal Investigator: Michael Lanspa, MD
Phone: 801-507-6556
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
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