Cerebral Palsy Adult Transition Longitudinal Study

The investigators are proposing a prospective, longitudinal, cross-sectional, and
patient-centered outcome study of walking ability and current health status to investigate
important health outcomes that impact the quality of life, participation, and activity on
adults with cerebral palsy who took part in a gait analysis during childhood at the Center
for Gait and Movement Analysis (CGMA). The goal is to see whether their health and walking
ability has changed since leaving the Children's Hospital Colorado (CHCO) system and
understand if there is a relationship between maintaining proper walking ability and health
status. The investigators are including the measure of health outcomes to better understand
if a decline in walking ability relates to a decline in health status. The first aim is to
study the walking ability of adults with cerebral palsy by comparing their results of a gait
analysis to the same results collected when they were children. The second aim is to study
the presence of heart disease risk factors by testing each participant's blood levels of
lipids, glucose, and insulin. The investigators will also measure each participant's blood
pressure. The third aim is to study the relationship(s) between inflammatory markers,
neurotrophic factors, and pain and fatigue levels. The investigators will measure
inflammatory markers through a blood test and pain and fatigue levels through standardized
assessments. The fourth aim is to study each participant's mental health. The investigators
will measure this through standardized psychological assessments. The fifth aim is to study
each participant's self-perceived health and quality of life as well as employment status.
The investigators will measure these levels also through standardized assessments.

Inclusion Criteria:

- Male and female adults (aged 18 years or older) with cerebral palsy (CP)

- Adults with CP who are part of the CGMA data registry

- Adults with CP who have previously participated in an IGA at the CGMA

- Adults with CP who are able to walk (with or without assistance) three times down a
~35 foot walkway at a comfortable and self-selected pace

- Adults with CP who are able to give informed consent, or have a legally authorized
representative to give informed consent

- Adults with CP who are able to understand and communicate in English or Spanish
(medical interpreters will be utilized for this study when needed)

- If medicated, adults with CP will need to be on a stable medication regimen for at
least six months prior to study enrollment (including non-steroidal anti-inflammatory
drugs (NSAIDs))

- Adults with CP who are able to devote sufficient time to participate in a
health/physical exam, respond to questions asked during assessments, and participate
in an IGA

- Adults with CP who have no recent history of seizure or blackout

Exclusion Criteria:

- Male and female children (aged 17 years or younger) with CP

- Adults with CP who have never participated in an IGA at the CGMA

- Adults with CP whose mobility is impaired to the point of being unable to move (even
with assistance)

- Adults with CP who are taking any medication(s) that might interfere with the ability
to move

- Adults with CP who are unable to devote sufficient time to participate in a
health/physical exam, respond to questions asked during assessments, and participate
in an IGA

- Adults with CP who have any medical issue impacting performance