Multiple Sclerosis-Collaborative Approach to Rehabilitation Effectiveness Study

Background: It is common for people with multiple sclerosis (MS) to have depression and
chronic pain. Individuals with MS who have depression and/or pain often use more health care
services, benefit less from treatment, and have poorer quality of life. While evidence-based
medical and behavioral treatments for depression and pain exist, they are often not offered
or accessible to persons with MS. As a result, chronic pain and depression are under-treated
in people with MS. One way to better treat these problems is through a "Collaborative Care"
approach. In this approach a care manager (nurse supervised by expert physicians,
psychiatrists, and psychologists) helps coordinate and provide high-quality, evidence-based
treatments for depression and pain. The care manager also makes sure that the care is focused
on the patient's goals and preferences. The care is provided by phone or in person based on
the patient's preference. Although this approach has been used successfully with patients
with many different conditions, it has never been tested in patients with MS, pain, and
depression.

Objectives: The investigators' objectives are to (1) test the benefits of the
patient-centered collaborative care treatment approach for persons with MS who also have
depression and/or pain; and also (2) test whether this approach improves quality of life,
patient satisfaction, adherence to other treatments, and quality of care in the MS care
system.

Methods: Participants were 195 outpatients with MS from a specialty MS Center who had
depression and/or chronic pain. Half of the participants received the treatment that was
typical for patients in the MS Center ("usual care"), while the other half received treatment
using the Collaborative Care approach. Participants in the collaborative care group met
regularly in-person or by telephone with a social worker who coordinated their depression and
pain treatments and provided strategies for better managing their symptoms. The treatment
phase of the study lasted for 16 weeks and began within 2 weeks of study enrollment.
Participants completed telephone interviews within 2 weeks of enrollment, approximately 4
months after study enrollment, and approximately 10 months after study enrollment. During
these interviews participants were asked questions about their pain, depression, satisfaction
with care, and quality of life to compare the two care approaches.

Projected Patient Outcomes: The investigators anticipate that those in the collaborative care
approach will have better controlled pain and depression and better quality of life,
satisfaction with care, adherence to other MS treatments, and quality of care compared to
those in the usual care approach. The results of this study may help patients, clinicians,
healthcare system leaders, and policy makers make decisions about the benefits of this type
of coordinated care approach for depression and pain in MS care.

Inclusion Criteria:

- Patient has a definitive diagnosis of MS confirmed by subjects' MS physician in the
University of Washington (UW) MS Center;

- Patient has received care and plans to continue to receive care at the UW MS Center
during enrollment period;

- Patient has access to and is able to communicate over the telephone (we will provide
phone headsets if needed) to allow participation in the telehealth components of the
study;

- Patient can read, speak and understand English;

- Patient is at least 18 years of age.

- Patient reports a clinically significant problem with pain and/or depression.

Exclusion Criteria:

- Patient represents a high suicide risk;

- Patient reports symptoms of a current psychotic disorder or diagnosis of bipolar
disorder with current psychotic features at time of screening;

- Subject attends appointments more than once per month with a psychiatrist for
treatment of depression;

- Patient reports planning major surgery in the next ten months;

- Patient reports alcohol or psycho-active substance dependence within past month;

- Patient has moderate to severe cognitive impairment.