The WISE (Weightloss Intervention Surgical Effects) Brain Study
| Status: | Recruiting |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 75 |
| Updated: | 1/6/2019 |
| Start Date: | August 2014 |
| End Date: | January 2020 |
| Contact: | Roxanne Rezaei |
| Email: | roxanne.rezaei@phhp.ufl.edu |
| Phone: | 352-294-5818 |
Obesity and Type 2 Diabetes, Bariatric Surgery Effects on Brain Function
This study is being done to learn about the changes that weight loss causes on brain
function, memory and thinking ability in adults. The study does NOT cover any costs
associated with bariatric surgery.
function, memory and thinking ability in adults. The study does NOT cover any costs
associated with bariatric surgery.
There will be two groups of people studied:
One group has chosen (independently of this research study) to have weight loss surgery to
help them lose weight.
Another group will not choose to have any weight loss surgery. All research participants will
be tested on thinking and memory processes at the start of the study, after 12 weeks, and
again at 18 months. They will have an MRI Brain Scan at those same times also to look at
changes in the structure and function of the brain tissue.
Blood tests will be done to measure the sugar levels in the blood, and other proteins that
may act as markers for disease.
One group has chosen (independently of this research study) to have weight loss surgery to
help them lose weight.
Another group will not choose to have any weight loss surgery. All research participants will
be tested on thinking and memory processes at the start of the study, after 12 weeks, and
again at 18 months. They will have an MRI Brain Scan at those same times also to look at
changes in the structure and function of the brain tissue.
Blood tests will be done to measure the sugar levels in the blood, and other proteins that
may act as markers for disease.
Inclusion Criteria:
- Body Mass Index >35
- Diabetes or no diabetes
- Compatible with MRI Scanning
- Willing to give a small blood sample on 3 occasions
- Capable of providing informed consent
Exclusion Criteria:
- Prior neurological disorder
- Mini Mental Status Exam score
- Major psychiatric disturbance (schizophrenia, chronic intractable depression,
- Coronary revascularization, peripheral vascular disease
- Severe cardio vascular disease history
- Unstable medical conditions (cancer)
We found this trial at
1
site
1225 Center Drive
Gainesville, Florida 32610
Gainesville, Florida 32610
Phone: 352-294-5818
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