Aromatase Inhibitor Growth Study: Letrozole vs. Anastrozole
| Status: | Recruiting |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 10 - 17 |
| Updated: | 4/2/2016 |
| Start Date: | November 2009 |
| Contact: | E Kirk Neely, MD |
| Email: | neely@stanford.edu |
| Phone: | 650 723-5791 |
Randomization to Letrozole vs. Anastrozole in Short Pubertal Males
The purpose of the study is to determine if there are differences in the final height or
hormone profile of short pubertal boys placed on different forms of aromatase inhibitor now
routinely used to increase stature: Anastrozole and Letrozole. It also should determine if
there are differences in the side effect profiles of the two drugs to be used.
hormone profile of short pubertal boys placed on different forms of aromatase inhibitor now
routinely used to increase stature: Anastrozole and Letrozole. It also should determine if
there are differences in the side effect profiles of the two drugs to be used.
Inclusion Criteria:
- Current height less than 5th percentile AND/OR
- Predicted adult height (based on bone age) more than 10 cm below target height (mid
parental height)
- Evidence of puberty: physical signs and serum luteinizing hormone > 0.3 IU/L and
testosterone > 15 ng/dl
Exclusion Criteria:
- Bone age reading more than 14.0 years
- Follicle stimulating hormone > 20 IU/L
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