Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma

PRIMARY OBJECTIVES:

I. Evaluate the tolerance and clinical response of Kaposi sarcoma (KS) tumors to PF-03084014
(gamma secretase inhibitor PF-03084014) with assessments of partial response (PR) and
complete response (CR).

SECONDARY OBJECTIVES:

I. Assess the effect of PF-03084014 on human immunodeficiency virus (HIV) viral load in
plasma and the effect of PF-03084014 on cluster of differentiation (CD)4+ cell number.

II. Assess the effect of PF-030840414 in peripheral blood mononuclear cells (PBMCs) and
tumors on Kaposi's sarcoma-associated herpesvirus (KSHV) latent and lytic gene expression.

III. Assess effects of PF-03084014 on activation of Notch target genes including
tumor-associated endothelial-mesenchymal transition and cell proliferation markers.

IV. Assess effects of trough PF-03084014 drug levels on clinical response and toxicity.

OUTLINE:

Patients receive gamma secretase inhibitor PF-03084014 orally (PO) twice daily (BID) on days
1-21. Treatment repeats every 21 days for up to 4 courses in the absence of disease
progression or unacceptable toxicity. Patients with PR, CR, or stable disease (SD) at the
end of 4 courses may receive an additional 4 courses of gamma secretase inhibitor
PF-03084014 in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 28 days.

Inclusion Criteria:

- Biopsy-proven KS involving skin, with or without visceral involvement, either newly
diagnosed or refractory to or intolerant of one or more prior therapies

- Participants must have cutaneous lesion(s) amenable to four total biopsies (either
four lesions > 4 mm or one large lesion measuring 20 mm that can undergo serial
biopsy) and at least five additional lesions measurable for assessment with no
improvement over the past month

- There should be no evidence for improvement in KS in the 3 months prior to study
entry, unless there is also evidence for progression of KS in the 4 weeks immediately
prior to study entry

- Serologic documentation of HIV infection by any of the Food and Drug Administration
(FDA)-approved tests

- Karnofsky performance status >= 60%

- All participants must be on antiretroviral therapy for HIV infection with CD4 count >
50/mm^3 and viral load < 2,000 copies/mL; participants must be on a stable regimen
for at least 12 weeks prior to study entry; participants may receive any FDA approved
antiretroviral therapy except for zidovudine or boosted protease inhibitors

- If antiretroviral regimen contains zidovudine or strong cytochrome P450, family
3, subfamily A, polypeptide 4 (Cyp3A4) inhibitors (e.g. ritonavir or
cobicistat-boosted protease inhibitors) and viral load is suppressed (as
measured by HIV viral load =< 200/mL), then antiretroviral therapy must be
adjusted to a less toxic therapy not containing these antivirals and enrollment
may proceed without waiting 12 weeks

- If on antiviral therapy with zidovudine or boosted protease inhibitors, and
viral load is not suppressed (as measured by HIV viral load >= 200/mL), then
antiretroviral therapy must be adjusted to a less toxic regimen allowing for
optimal viral suppression and must demonstrate stability for at least 12 weeks
prior to study entry

- Allowable antiretrovirals include nucleoside or nucleotide inhibitors other than
zidovudine, non-nucleoside inhibitors, non-boosted protease inhibitors,
integrase inhibitors raltegravir or dolutegravir, or entry inhibitors maraviroc
or enfuvirtide

- Hemoglobin >= 8 g/dL

- Absolute neutrophil count (ANC) >= 1,000 cells/mm^3

- Platelet count >= 100,000/mm^3

- Calculated (method of Cockcroft-Gault) creatinine clearance (CrCl) >= 60 mL/min
(creatinine clearance may also be obtained by the 24-hour collection method at the
investigator's discretion)

- Total bilirubin should be =< 1.5 x upper limit of normal (ULN); if, however, the
elevated bilirubin is felt to be secondary to atazanavir therapy, participants will
be allowed to enroll on protocol if the total bilirubin is =< 3.5 mg/dL provided that
the direct bilirubin is normal

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and
alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x
ULN

- Life expectancy >= 3 months

- Ability and willingness to give informed consent

- Females of childbearing potential (FCBP) must have a negative serum or urine
pregnancy test with a sensitivity of at least 50 mIU/mL (milli-International units
per milliliter) within 10-14 days prior to and again within 24 hours of starting
PF-03084014 and must either commit to continued abstinence from heterosexual
intercourse or begin TWO acceptable barrier methods of birth control AT THE SAME
TIME, at least 28 days before she starts taking PF-03084014, during receipt of
PF-03084014, and 6 months after discontinuation of PF-03084014; FCBP must also agree
to ongoing pregnancy testing; men must agree to use a latex condom during sexual
contact with a FCBP even if they have had a successful vasectomy

- A female of childbearing potential is a sexually mature woman who: 1) has not
undergone a hysterectomy or a bilateral oophorectomy; or 2) has not been
naturally postmenopausal for at least 24 consecutive months (i.e., has had
menses at any time in the preceding 24 consecutive months)

- Participants must, in the opinion of the investigator, be capable of complying with
the protocol

Exclusion Criteria:

- Concurrent, acute, active opportunistic infection other than oral thrush or genital
herpes within 14 days of enrollment

- Acute treatment for an infection (other than oral thrush or genital herpes) or other
serious medical illness within 14 days of study entry

- Participants for whom front-line cytotoxic therapy is indicated (i.e., symptomatic
visceral or pulmonary KS or symptomatic KS impairing functional status); all
participants must have a chest X-ray to rule out pulmonary KS within 28 days of study
enrollment

- Concurrent neoplasia requiring cytotoxic therapy

- Anti-neoplastic treatment for KS (including chemotherapy, radiation therapy, local
therapy including topical fluorouracil [5-FU], biological therapy, or investigational
therapy) within four weeks of study entry

- Any steroid treatment except for that required for replacement therapy in adrenal
insufficiency or inhaled steroids for the treatment of asthma

- Patient is =< 2 years free of another primary malignancy; exceptions include the
following:

- Cervical carcinoma in situ

- Anal carcinoma in situ

- Previous local therapy of any KS-indicator lesion unless the lesion has clearly
progressed since treatment; any prior local treatment to indicator lesions regardless
of the elapsed time is not allowed unless there is evidence of clear-cut progression
of said lesion

- Use of any investigational drug or treatment within 4 weeks prior to enrollment

- Physical or psychiatric conditions that in the estimation of the investigator place
the patient at high risk of toxicity or non-compliance

- Female participants who are breast-feeding

- Participants requiring blood transfusions to maintain hemoglobin (Hgb) eligibility

- Participants currently receiving zidovudine, or strong CYP3A4 inhibitors (e.g.
cobicistat (currently only in Stribild® or ritonavir boosted antiretroviral
regimens), ketoconazole, itraconazole, erythromycin, clarithromycin, dexamethasone,
phenobarbital, rifampin, phenytoin, carbamazepine, rifabutin, rifapentine, St John's
Wort, tacrolimus, cyclosporine, oral contraceptives, warfarin, docetaxel, sirolimus,
or other strong inhibitors or inducers of CYP3A4 or substrates of CYP3A4 that have a
narrow therapeutic margin