Continuous Hemoglobin Monitoring: Detection of Acute Blood Loss - Accurate, Timely and Cost-effective

The purpose of the study is to determine whether noninvasive hemoglobin monitoring is
sensitive and accurate enough to detect a significant downward trend in hemoglobin in
patients at risk for significant bleeding. If this can be shown, it has the potential to
spare patients multiple invasive blood draws as well as allow for earlier detection of
significant blood loss and therefore positively impact on patient morbidity and mortality.
Additionally, it may represent significant financial cost savings in that it may allow for
patients to be monitored in a non-intensive care unit setting.

This will be an observational study. The continuous hemoglobin monitor will be connected to
the patient and hemoglobin measurement data will be collected. Routine laboratory hemoglobin
monitoring will occur concurrently at a pre-specified frequency as well as at the
physician's discretion based on usual clinical information. The physician will be blinded to
the continuous hemoglobin monitoring readings and therefore patient care will not be
affected by the use of the monitor. Once the study has ended, the data will then be analyzed
to assess for correlation between continuous hemoglobin monitoring readings and laboratory
hemoglobin measurement.