Bone Health in Youth With Type 1 Diabetes
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Osteoporosis, Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology, Rheumatology |
| Healthy: | No |
| Age Range: | 10 - 16 |
| Updated: | 1/6/2019 |
| Start Date: | August 2013 |
| End Date: | July 2020 |
Bone Mineral Accrual and Microarchitecture in Youth With Type 1 Diabetes
This is an observation study of girls ages 10-16 years with type 1 diabetes and age- and
race-matched controls. The investigators will be examining blood and urine hormone levels as
well as measures of bone density including DXA and high-resolution peripheral quantitiative
computed tomography. The investigators hypothesize that youth with type 1 diabetes will have
slower bone accrual and impaired bone microarchitectural integrity compared with non-diabetic
controls. The investigators hypothesize that poor bone accrual will be associated with
sub-optimal glucose control as well as lower levels of insulin-like growth factor 1.
race-matched controls. The investigators will be examining blood and urine hormone levels as
well as measures of bone density including DXA and high-resolution peripheral quantitiative
computed tomography. The investigators hypothesize that youth with type 1 diabetes will have
slower bone accrual and impaired bone microarchitectural integrity compared with non-diabetic
controls. The investigators hypothesize that poor bone accrual will be associated with
sub-optimal glucose control as well as lower levels of insulin-like growth factor 1.
Inclusion Criteria:
- Female
- Age 10-16 years
- Diagnosed with type 1 diabetes > 1 year (diabetic cohort)
Exclusion Criteria:
- BMI<5th percentile for age
- BMI>95th percentile for age
- Celiac disease
- Hyperthyroidism, uncontrolled hypothyroidism
- History of significant hepatic disease, renal disease, oncologic disease,
cardiovascular disease, psychiatric disease
- Anemia (Hgb <11)
- Taking medications other than insulin known to affect bone health (including hormonal
contraception, glucocorticoids, growth hormone)
We found this trial at
1
site
185 Cambridge Street
Boston, Massachusetts 02114
Boston, Massachusetts 02114
617-724-5200
Phone: 617-724-2034
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