OCT in Rare Chorioretinal Diseases

Optical coherence tomography (OCT) is an imaging technology that can perform non-contact
cross-sectional imaging of retinal and choroidal tissue structure in real time by measuring
the intensity of reflected light. Tomographic images are generated by scanning the optical
probe beam across the tissue structure of interest. OCT has become one of the most widely
used imaging technologies by ophthalmologists. Its advantages include being a non-contact
imaging modality, having micron-level resolution, producing a digital image that can be
viewed electronically, and providing a reproducible quantitative measurement. New functional
OCT including Doppler OCT and OCT angiography may allow an assessment of retinal blood flow
and do away with the need for the more invasive fluorescein angiography (FA) test.

Thus, if the diagnostic data provided by functional OCT are at least equivalent or superior
to those achieved by FA, patients and healthcare providers could realize a substantial
benefit in utilizing this technology in the evaluation of retinal vascular disease. Even in
the scenario in which an FA is not usually clinically indicated, OCT angiography may provide
information over that of standard OCT and clinical examination and history, that might help
clinicians better understand the etiology of the disease, and may even help inform treatment
response.

Subject-Level Criteria:

Inclusion a. Diagnosis of retinal or choroidal disease

Exclusion

1. Inability to give informed consent.

2. Inability to complete study tests within a 30 day period

3. Significant renal disease, defined as a history of chornic renal failure requiring
dialysis or kidney transplant.

4. A condition that, in the opinion of the investigator, would preclude participation in
the study (e.g. unstable medical status including blood pressure, cardiovascular
disease, and glycemic control).

5. Blood pressure > 180/110 (systolic above 180 OR diastolic above 110). If blood
pressure is brought below 180/110 by anti-hypertensive treatment, subject can become
eligible.

6. Women of child-bearing potential: pregnant or lactating or intending to become
pregnant within the next 12 months due to unknown safety of fluorescein angiography.

Study-Eye Criteria:

Inclusion

a. Diagnosis of retinal or choroidal disease

Exclusion

1. Inability to maintain stable fixation for OCT imaging.

2. An ocular condition is present that, in the opinion of the investigator, might affect
or alter visual acuity during the course of the study (i.e. cataract)

3. Substantial cataract that, in the opinion of the investigator, is likely to decrease
visual acuity by 3 lines or more (i.e. cataract would be reducing acuity to 20/40 or
worse if the eye was otherwise normal).

4. Media opacity or otherwise that would prevent either fixation or ability to obtain
adequate images as determined by the examiner.