Computerized Cognitive Exercise Training Treatment for Adults With Multiple Sclerosis
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology, Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 10/14/2017 |
| Start Date: | September 2013 |
Plasticity-based, Adaptive, Computerized Cognitive Remediation Treatment (PACR) for Adults With Multiple Sclerosis (MS)
Cognitive impairment remains a major disability for individuals with multiple sclerosis (MS).
The primary objective of this study is to evaluate the efficacy for treating MS-associated
cognitive deficits using a unique computer-based plasticity-based and adaptive cognitive
remediation treatment (PACR) compared to a computer-based control. This novel cognitive
remediation approach has led to striking improvements in cognitive functioning in other
disorders (schizophrenia, traumatic brain injury, aging, and dementia) but has never been
applied to individuals with MS. The investigators will enroll 136 MS participants who will be
randomized in a 2:1 pattern to complete either the treatment or control condition for 60
hours across a 12-week treatment period. Both the treatment and control conditions will be
accessed remotely by the subjects from a study-provided laptop computer. Study outcomes will
include program compliance, performance on study tasks and neuropsychological measures,
quality of life and functional status. Given the success of this program with other disorders
and strong preliminary data from our feasibility study, the investigators believe PACR is an
exciting untapped opportunity to improve cognition in individuals with MS.
The primary objective of this study is to evaluate the efficacy for treating MS-associated
cognitive deficits using a unique computer-based plasticity-based and adaptive cognitive
remediation treatment (PACR) compared to a computer-based control. This novel cognitive
remediation approach has led to striking improvements in cognitive functioning in other
disorders (schizophrenia, traumatic brain injury, aging, and dementia) but has never been
applied to individuals with MS. The investigators will enroll 136 MS participants who will be
randomized in a 2:1 pattern to complete either the treatment or control condition for 60
hours across a 12-week treatment period. Both the treatment and control conditions will be
accessed remotely by the subjects from a study-provided laptop computer. Study outcomes will
include program compliance, performance on study tasks and neuropsychological measures,
quality of life and functional status. Given the success of this program with other disorders
and strong preliminary data from our feasibility study, the investigators believe PACR is an
exciting untapped opportunity to improve cognition in individuals with MS.
Inclusion Criteria:
- Ages 18-70
- Definite MS Diagnosis, any subtype [83]
- Probable cognitive impairment as defined by a score ≤ 1 SD below the mean of normative
data on the SDMT
- Concurrent medications to be kept constant over three months (as possible)
- No relapse or steroids in previous month
- Reading score on WRAT-3 of 37 or greater
- Visual, auditory and motor capacity to operate computer software, as judged by
treating neurologist or study staff
- Willing to sign Agreement to Borrow Laptop
Exclusion Criteria:
- History of mental retardation, pervasive developmental disorder or other neurological
condition associated with cognitive impairment
- Primary psychiatric disorder that would influence ability to participate
- Other serious uncontrolled medical condition (e.g., cancer or acute myocardial
infarction)
- Alcohol or other substance use disorder
- History of computer-based training manufactured by Posit Science
- Learned English language after 12 years of age
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