n-Acetylcysteine and Cocaine
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Psychiatric, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 55 |
| Updated: | 5/12/2016 |
| Start Date: | May 2014 |
| End Date: | April 2016 |
Motivation for Cocaine and Non-Drug Reinforcers: Targeting Glutamate Homeostasis
This study will determine the initial efficacy, safety and tolerability of n-acetylcysteine
as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study
will be conducted in which the subjective, physiological and reinforcing effects of cocaine
are evaluated during maintenance on placebo and n-acetylcysteine.
as a pharmacotherapy for cocaine dependence. A rigorous, inpatient human laboratory study
will be conducted in which the subjective, physiological and reinforcing effects of cocaine
are evaluated during maintenance on placebo and n-acetylcysteine.
Inclusion Criteria:
- Current cocaine use
- Current cigarette smoker
Exclusion Criteria:
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians
deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the
study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired
cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure
or current or past histories of serious psychiatric disorder that in the opinion of
the study physician would interfere with study participation will be excluded from
participation
- Females not currently using effective birth control
- Contraindications to cocaine or n-acetylcysteine
- History of schizophrenia in first degree relative
We found this trial at
1
site
Lexington, Kentucky 40507
Principal Investigator: William W Stoops, PhD
Phone: 859-257-5388
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