A Phase 2 Study to Investigate the Safety and Efficacy of ABT-122 Given With Methotrexate in Subjects With Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate

Inclusion Criteria: 1. Adult male or female, 18 years of age or older. 2. Diagnosis of RA
based on the 2010 American College of Rheumatology (ACR)/European League against
Rheumatism (EULAR) criteria (as defined in the definition of terms).

3. Rheumatoid Arthritis (RA) diagnosis at least 3 months from the date of first Screening.

4. Have active RA defined by minimum disease activity criteria:

- ≥ 6 Swollen joints (based on 66 joint counts) at screening and baseline visits.

- ≥ 6 Tender joints (based on 68 joint counts) at screening and baseline visits.

- hsCRP> ULN OR positive for both Rheumatoid Factor (RF) and Anti-Cyclic Citrullinated
Peptide (Anti-CCP) Antibody levels at screening. 5. Inadequate response to
Methotrexate (MTX) treatment defined as oral or parenteral treatment ≥ 3 months with
an unchanged mode of application and stable prescribed MTX dose for at least 4 weeks
prior to baseline of ≥ 10mg/week and < the upper limit of the applicable approved
local label. Subject can also be on stable doses of sulfasalazine and/or
hydroxychloroquine, so long as they are also on methotrexate.

Exclusion Criteria: 1. Subject has previous exposure to Humira, other Tumor necrosis
factor (TNF) inhibitors or other biological DMARDs.

2. Current treatment with traditional oral Disease modifying antirheumatic drugs (DMARDs)
(except for concomitant treatment with sulfasalazine and/or hydroxychloroquine in addition
to MTX). Oral DMARDs must be washed out 5 times the mean terminal elimination half-life of
a drug apart from MTX prior to Day 1.

- Subject could have been exposed to prior Janus kinase (JAK) inhibitors so long as
they have been off therapy for 5 half-lives.

3. Stable prescribed dose of oral prednisone or prednisone equivalent > 10 mg/day
within the 30 days of first dose of study drug.

4. Intra-articular or parenteral administration of corticosteroids in the preceding 4
weeks of first dose of study drug. Inhaled corticosteroids for stable medical
conditions are allowed.

5. Laboratory values of the following at the Screening Visit:

- Confirmed hemoglobin < 9 g/dL for males and < 8.5 g/dL for females,

- Absolute neutrophil count (ANC) < 1500 mm^3,

- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 1.5 × the upper
limit of normal (ULN) or bilirubin ≥ 3 mg/dL,

- Serum creatinine > 1.5 × the ULN,

- Platelets < 100,000 cells/[mm3] (10^9/L),

- Clinically significant abnormal screening laboratory results as evaluated by the
Investigator.