Intraperitoneal Floxuridine in Gastric Carcinoma

Patients undergoing curative resection for gastric cancer have been shown to benefit from
postoperative chemotherapy with 5-fluoruracil + leucovorin, and radiation in an Intergroup
Study (INT116). However, both local and distal relapses still occur in 50% at 3 years. This
study is based on the hypothesis that 2 cycles (of 3 days each 2 weeks apart) of
intraperitoneal FUDR (floxuridine), followed by the above treatment will improve outcome.