OnabotulinumtoxinA Treatment in Adult Patients With Upper Limb Spasticity

Inclusion Criteria:

- Upper limb spasticity in the elbow and shoulder due to stroke, with the most recent
stroke at least 3 months ago

Exclusion Criteria:

- Spasticity in the non-study upper limb that requires treatment

- Presence of fixed contractures in of the study muscles in elbow or shoulder

- Profound atrophy of muscles to be injected

- Previous surgical intervention, nerve block, or muscle block for the treatment of
spasticity in the study limb in the last 12 months

- Injection of corticosteroids or anesthetics, use of casting or dynamic splinting or
constraint-induced movement therapy (CIMT) for the study limb within 3 months

- Ultrasound therapy, electrical stimulation, or acupuncture in the study limb within 1
month

- Condition other than stroke contributing to upper limb spasticity

- Diagnosis of myasthenia gravis, Eaton-Lambert syndrome, and/or amyotrophic lateral
sclerosis