A Prospective Randomized Controlled Clinical Trial of Standard Versus Goal-Directed Perioperative Fluid Management (GDT) for Patients Undergoing Radical Cystectomy

Inclusion Criteria:

- Adults (21 years old or greater) who are able to provide informed consent

- Patients who undergo an open, elective radical cystectomy

Exclusion Criteria:

- Patients with active atrial fibrillation or flutter, since the algorithm is not
accurate in case of cardiac arrhythmia

- Female patients who are pregnant (female patients of child-bearing potential must have
a negative serum pregnancy test ≤ 14 days prior to surgery or 15 to 30 days prior to
surgery with a negative urine pregnancy test the morning of surgery)

- Presence of ascites, because increased abdominal pressure interferes with EV1000
reading accuracy

- BMI > 45 or <17, because increased abdominal pressure interferes with EV1000 reading
accuracy