A Study to Assess Immune Response Following Zoster Vaccination to Subjects With Rheumatoid Arthritis Receiving Tofacitinib or Placebo With Background Methotrexate



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:50 - Any
Updated:4/17/2018
Start Date:June 2014
End Date:July 2015

Use our guide to learn which trials are right for you!

A Randomized, Double-blind, Placebo-controlled, Phase 2 Study To Assess The Immune Response Following Administration Of Zoster Vaccine To Subjects With Rheumatoid Arthritis Receiving Tofacitinib (Cp-690,550) Or Placebo With Background Methotrexate Treatment

This study will evaluate immune response following administration of zoster vaccine in
subjects with rheumatoid arthritis who are receiving background methotrexate and initiate 5
mg twice daily of tofacitinib or placebo for tofacitinib 2 to 3 weeks following vaccination.


Inclusion Criteria:

- Subjects must have moderate to severe rheumatoid arthritis inadequately controlled by
methotrexate as defined by the American College of Rheumatology (ACR) classification
criteria for Rheumatoid arthritis, painful and swollen joint counts and C-reactive
protein (CRP).

- Screening CRP >3 mg/L or CDAI score > 10 at screening or at baseline before
vaccination.

- Subjects must have active disease at screening and baseline.

- Must be at least 50 years of age or older.

Exclusion Criteria:

- History of receiving any varicella-zoster virus vaccine

- Receipt of any vaccines within 6 weeks of first dose of study treatment.

- Subjects with current infections or history of infections.

- History of recurrent (more than one episode) of herpes zoster or disseminated (a
single episode) of herpes zoster or disseminated (a single episode) of herpes simplex.
We found this trial at
36
sites
Knoxville, Tennessee 37909
?
mi
from
Knoxville, TN
Click here to add this to my saved trials
4085 University Blvd S # 1
Jacksonville, Florida 32216
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
Albany, New York 12206
?
mi
from
Albany, NY
Click here to add this to my saved trials
?
mi
from
Allen, TX
Click here to add this to my saved trials
Bethlehem, Pennsylvania 18015
?
mi
from
Bethlehem, PA
Click here to add this to my saved trials
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Duncansville, Pennsylvania 16635
?
mi
from
Duncansville, PA
Click here to add this to my saved trials
Frederick, Maryland 21702
?
mi
from
Frederick, MD
Click here to add this to my saved trials
Greenville, South Carolina 29607
?
mi
from
Greenville, SC
Click here to add this to my saved trials
Hickory, North Carolina 28602
?
mi
from
Hickory, NC
Click here to add this to my saved trials
Hickory, North Carolina 28602
?
mi
from
Hickory, NC
Click here to add this to my saved trials
Indianapolis, Indiana 46227
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Jackson, Tennessee 38305
?
mi
from
Jackson, TN
Click here to add this to my saved trials
Jackson, Tennessee 38305
?
mi
from
Jackson, TN
Click here to add this to my saved trials
Jonesboro, Arkansas 72401
?
mi
from
Jonesboro, AR
Click here to add this to my saved trials
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
?
mi
from
Lebanon, NH
Click here to add this to my saved trials
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Los Angeles, California 90095
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
?
mi
from
Miami, FL
Click here to add this to my saved trials
New Port Richey, Florida 34652
?
mi
from
New Port Richey, FL
Click here to add this to my saved trials
Orchard Park, New York 14127
?
mi
from
Orchard Park, NY
Click here to add this to my saved trials
Pinellas Park, Florida 33782
?
mi
from
Pinellas Park, FL
Click here to add this to my saved trials
Port Richey, Florida 34668
?
mi
from
Port Richey, FL
Click here to add this to my saved trials
Port Richey, Florida 34668
?
mi
from
Port Richey, FL
Click here to add this to my saved trials
12450 Roosevelt Boulevard North
Saint Petersburg, Florida 33782
?
mi
from
Saint Petersburg, FL
Click here to add this to my saved trials
Saint Petersburg, Florida 33710
?
mi
from
Saint Petersburg, FL
Click here to add this to my saved trials
Salisbury, North Carolina 28147
?
mi
from
Salisbury, NC
Click here to add this to my saved trials
Salisbury, North Carolina 28144
?
mi
from
Salisbury, NC
Click here to add this to my saved trials
Santa Maria, California 93454
?
mi
from
Santa Maria, CA
Click here to add this to my saved trials
Sarasota, Florida 34239
?
mi
from
Sarasota, FL
Click here to add this to my saved trials
Tampa, Florida 33607
?
mi
from
Tampa, FL
Click here to add this to my saved trials
?
mi
from
Upland, CA
Click here to add this to my saved trials
Vancouver, Washington 98664
?
mi
from
Vancouver, WA
Click here to add this to my saved trials
Vancouver, Washington 98664
?
mi
from
Vancouver, WA
Click here to add this to my saved trials
Vernon Hills, Illinois 60061
?
mi
from
Vernon Hills, IL
Click here to add this to my saved trials
Wyomissing, Pennsylvania 19610
?
mi
from
Wyomissing, PA
Click here to add this to my saved trials