Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 39 |
| Updated: | 4/21/2016 |
| Start Date: | March 2013 |
| End Date: | March 2016 |
| Contact: | Katie Sy |
| Email: | katrina.sy@cshs.org |
| Phone: | 3102487641 |
This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control
of the human cardiovascular system. Hookah smoking is known to transiently increase blood
pressure and heart rate while decreasing heart rate variability suggesting - but not proving
- sympathetic mediation. Here the investigators will directly measure the acute effects of
Hookah smoking on sympathetic nerve activity with microneurography (intraneural
microelectrodes) and quantify associated regional changes in vasomotor tone.
of the human cardiovascular system. Hookah smoking is known to transiently increase blood
pressure and heart rate while decreasing heart rate variability suggesting - but not proving
- sympathetic mediation. Here the investigators will directly measure the acute effects of
Hookah smoking on sympathetic nerve activity with microneurography (intraneural
microelectrodes) and quantify associated regional changes in vasomotor tone.
Inclusion Criteria:
- 18 to 39 years of age
- Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12
months
- Have not smoked cigarettes within the past 12 months
Exclusion Criteria:
- Exhaled carbon monoxide level greater than 10 ppm* as evidence of current or recent
cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded
if smoked Hookah within past 72 hours)
- History of cardiopulmonary disease
- Use of any prescription medication with exception of oral contraceptive pills
- History of psychiatric illness
- History of neurologic disease
- BMI ≥ 35
- Evidence of any of the above by physical examination, ECG or echocardiogram
- Smoked cigarette in the past 12 months
- History of illicit drug use
- Pregnant
- Any other condition(s) deemed by the physician investigators that put subjects at
risk for participating in the study
We found this trial at
1
site
8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Ronald G Victor, MD
Phone: 310-248-7641
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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