Cerebral Oxygenation and Autoregulation in Preterm Infants

Status:	Recruiting
Conditions:	Neurology, Women's Studies
Therapuetic Areas:	Neurology, Reproductive
Healthy:	No
Age Range:	Any
Updated:	4/21/2016
Start Date:	May 2014
End Date:	June 2017

Cerebral Oxygenation and Autoregulation in Preterm Infants: Association With Morbidity and Mortality

Premature infants are at high risk for variations in blood pressure and oxygenation during
the first few days of life. The immaturity of the premature brain may further predispose
these infants to death or the development of neurologic problems. The relationship between
unstable blood pressure and oxygen levels and brain injury has not been well elucidated.

This study investigates the utility of near-infrared spectroscopy (NIRS), a non-invasive
oxygen-measuring device, to identify preterm infants at highest risk for brain injury or
death.

Inclusion Criteria:

- inborn

- birth weight <= 1250 grams

- indwelling arterial catheter in place

- age <24 hours old

Exclusion Criteria:

- lethal chromosomal abnormality

- major congenital anomaly

- skin integrity insufficient to allow placement of NIRS sensors

- decision to not provide full intensive care

We found this trial at

sites

Nationwide Children's Hospital

700 Childrens Drive
Columbus, Ohio 43205

(616) 722-2000