Short Term Intermittent Fasting and Mediterranean Diet

The primary objective of this study is to determine whether or not IF, independently of
changes in quality of diet, reduces the level of chronic inflammation as evidenced by a
decrease in high sensitivity C-reactive protein (hsCRP), as the main outcome measure.

Inclusion Criteria:

1. - The participants in this study will be 50 men and women in the 30 to 65 year age
range, who have a BMI in the high-normal to moderately overweight range (i.e. 22 to 28
kg/m2),

2. - Participants who are eating usual US diets and are sedentary to moderately active
(i.e. not exercise trained).

3. - Participants have at least one of these metabolic abnormalities: pre-hypertension or
hypertension (i.e. systolic blood pressure > 120 mmHg or diastolic blood pressure > 80
mmHg or specific treatment of previously diagnosed hypertension)10, sub-optimal lipid
levels (i.e. LDL-cholesterol > 100 mg/dl or HDL-cholesterol < 59 mg/dl or specific
treatment for this lipid abnormality)11, impaired fasting glucose or glucose
intolerance (i.e. fasting glucose > 100 mg/dl or 2 hr-glucose during OGTT with a
glucose load of 75 g > 140 mg/dl or specific treatment for previously diagnosed type 2
diabetes)12, or high-risk waist circumference (≥ 94 cm in men and ≥ 80 cm in women)13.

Exclusion Criteria:

- 1 - History of any chronic disease process that could interfere with interpretation of
results 2 - Smoking, pregnancy, alcoholism, psychiatric problems, life situations that
would interfere with study participation and compliance.

3 - Currently eating diet similar to Mediterranean diet based on dietary and food frequency
questionnaires and 4-day food diary.