Peripheral Sensory Input in Central Post Stroke Pain (CPSP)



Status:Completed
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - Any
Updated:5/4/2018
Start Date:August 2014
End Date:January 25, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

How "Central" is Central Post-stroke Pain? Investigating the Role of Peripheral Sensory Input in Maintaining Central Pain

Prospective, open-label study in 10 patients with Central Post Stroke Pain (CPSP). The study
will evaluate the effects of peripheral nerve blockade on spontaneous pain and evoked thermal
and mechanical responses in CPSP, and assesses the associated local anesthetic
pharmacokinetics.


Each subject must meet all of the following criteria:

- Age ≥18;

- CPSP affecting an upper or a lower limb, in a distribution that may be completely
covered by a peripheral nerve block;

- Patient fulfills all mandatory criteria for CPSP, fulfills at least one supportive
criteria, and has definite CPSP by probability grading.

- Pain duration at least 3 months;

- Spontaneous pain intensity (average pain in past week) of ≥ 4 on 0-10 Numerical Rating
Scale (NRS).

Exclusion Criteria

Subjects will not be enrolled if any of the following criteria exist:

- Not giving consent to participate in the study;

- Significant psychiatric or cognitive impairment;

- Moderate to severe renal or liver failure;

- Concomitant treatment with warfarin or other anticoagulants;

- Pregnancy or lactation.
We found this trial at
1
site
Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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