Pharmacokinetics of Tivantinib in Subjects With Advanced Solid Tumors and Hepatic Impairment

Inclusion Criteria:

1. Subjects must have histologically or cytologically confirmed advanced solid tumor.
However, Hepatocellular Carcinoma (HCC) subjects are allowed without histological
confirmation as long as there is radiological diagnosis as per standard criteria

2. Male or female ≥18 years of age

3. Life expectancy of >12 weeks

4. Women of childbearing potential (WOCBP) must have a negative pregnancy test performed
prior to the start of study drug

5. Male subjects and WOCBP must agree to use double barrier contraceptive measures or
avoid intercourse during the study and for 90 days after the last dose of study drug

6. Subjects with impaired hepatic function will be grouped according to Child-Pugh
classification score

7. Subjects with biliary obstruction for whom a biliary drain or stent has been placed
are eligible, provided that the drain or stent has been in place for at least 10 days
prior to the first dose of Tivantinib, and the subject's liver function has stabilized
as defined by 2 measurements at least 5 days apart that put the subject in the same
hepatic impairment group

8. Eastern Cooperative Oncology Group (ECOG) performance status ≥2

9. Adequate bone marrow and renal function

10. Ability to provide written informed consent, comply with protocol visits and
procedures, take oral medication, and not have any active infection or chronic
comorbidity that would interfere with therapy

11. Fully informed about their illness and the investigational nature of the study
protocol and must sign and date an Institutional Review Board-approved Informed
Consent Form

Exclusion Criteria:

1. History of liver transplant

2. Any major surgical procedure within 3 weeks prior to the first dose of study drug;

3. Active, clinically serious infections defined as ≥Grade 2 according to NCI Common
Toxicity Criteria for Adverse Effects (CTCAE), version 4.0

4. Known metastatic brain or meningeal tumors, unless the subject is >3 months from
definitive therapy and clinically stable (supportive therapy with steroids or
anticonvulsant medications is allowed) with respect to the tumor at the time of the
first dose of study drug

5. History of cardiac disease

- Active coronary artery disease, defined as myocardial infarction, unstable
angina, coronary bypass graft, or stenting within 6 months prior to study entry

- Evidence of uncontrolled bradycardia or other cardiac arrhythmia defined as
≥Grade 2 according to NCI CTCAE, version 4.0, or uncontrolled hypertension

6. Any condition that is unstable or that could jeopardize the safety of the subject and
the subject's protocol compliance, including known infection with human
immunodeficiency virus

7. Significant gastrointestinal disorders, in the opinion of the Investigator

8. Pregnant or breastfeeding

9. Received Tivantinib as prior therapy

10. Received anti-cancer therapy, including antibody, retinoid, or hormonal treatment
(except megestrol acetate as supportive care), and radiation, within 3 weeks before
dosing. Prior and concurrent use of hormone replacement therapy, the use of
gonadotropin-releasing hormone modulators for prostate cancer, and the use of
somatostatin and analogs for neuroendocrine tumors are permitted

11. Any other investigational drug/medical device within 3 weeks prior to the first dose

12. Substance abuse or medical, psychological, or social conditions that, in the opinion
of the Investigator, may interfere with the subject's participation in the clinical
study or evaluation of the clinical study results

13. Subjects receiving Coumadin anticoagulants

14. Inability to swallow oral medications

15. Administration or possibility of initiating or continuing any treatment with any known
Cytochrome P450 3A4 (CYP3A4) and CYP2C19 enzyme and P-glycoprotein altering drugs
(inducer or inhibitor) or non drug agents within 14 days prior to dosing and during
the primary objective phase