Low-intensity Focused Ultrasound Pulsation (LIFUP) for Treatment of Temporal Lobe Epilepsy

Inclusion Criteria:

- Subjects with clinical evidence from their diagnostic evaluations of unilateral
hippocampal dysfunction and epileptogenicity.

- Subjects with seizures that have been refractory to treatment with at least three
currently marketed antiepileptic drugs.

- Subjects with epilepsy who would clearly benefit from surgical intervention.

- Subjects who have been offered a non-dominant anterior-mesial temporal lobe resection
as treatment for medication refractory epilepsy.

Exclusion Criteria:

- Subjects with a cognitive or psychiatric disorder that limits the ability to give
informed consent or are unable to cooperate with the testing.

- Subjects with dementia, delirium and psychotic symptoms. - Subjects with ferromagnetic
materials in the head.

- Subjects with severe cardiac disease, increased intracranial pressure, or a TENS unit.

- Subjects who exhibit primary generalized seizures or pseudoseizures.

- Subjects who have seizures secondary to drugs, alcohol, metabolic illness or
progressive degenerative disease.

- Subjects who have experienced status epilepticus during the 3-week baseline period
prior to the operation.

- Subjects (females) who are pregnant.