Neuromuscular Electrical Stimulation and Mobility in Multiple Sclerosis

Participants will be randomly assigned to one of two study arms. Those in one arm will
receive a treatment with narrow stimulus pulses (0.4 ms) and those in the other arm will
receive wide stimulus pulses (1 ms). The electrical stimulation will be delivered with a
Vectra Genisys System.

Inclusion Criteria:

- Able to read, understand, and speak English to ensure safe participation in the
project

- Difficulties with walking

- On stable doses of Ampyra, provigil, or other symptomatic-treating medications

- No systemic steroids within the last 30 days

- Not currently exercising more than 2x/wk

- Able to arrange own transportation to and from the laboratories

- Provide informed consent, including willingness to be randomly assigned to one of the
two groups

Exclusion Criteria:

- Documented MS-related relapse in the last 3 months

- Medical diagnosis or condition that is considered to be an absolute or relative
contraindication to participating in exercise training, such as major renal,
pulmonary, hepatic, cardiac, gastrointestinal, HIV, cancer (other than treated basal
cell cancer), other neurological disorders, or pregnancy

- Poorly controlled diabetes mellitus or hypertension

- History of seizure disorders

- Alcohol dependence or abuse (≥2 drinks/day), or present history (last 6 months) of
drug abuse

- Inability to attend exercise sessions 3 days per week for 6 weeks