Assessing the Efficacy of IV Ibuprofen for Treatment of Pain in Orthopedic Trauma Patients
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 2/9/2018 |
| Start Date: | October 2012 |
| End Date: | February 2018 |
STUDY OBJECTIVES:
1. To evaluate the effectiveness of around the clock (OTC) IV ibuprofen (8 doses) in
decreasing pain in orthopedic trauma patients with fractures of the extremities, face,
pelvis and/or ribs compared to patients not receiving the medication.
2. To evaluate the effectiveness of around the clock (OTC) IV ibuprofen (8 doses) in
decreasing the use of opioid analgesics among orthopedic trauma patients with fractures
of the extremities, face, pelvis, and/or ribs compared to compared to patients not
receiving the medication.
1. To evaluate the effectiveness of around the clock (OTC) IV ibuprofen (8 doses) in
decreasing pain in orthopedic trauma patients with fractures of the extremities, face,
pelvis and/or ribs compared to patients not receiving the medication.
2. To evaluate the effectiveness of around the clock (OTC) IV ibuprofen (8 doses) in
decreasing the use of opioid analgesics among orthopedic trauma patients with fractures
of the extremities, face, pelvis, and/or ribs compared to compared to patients not
receiving the medication.
Inclusion Criteria:
1. Trauma patient admitted to Trauma ICU or Trauma Step-Down Units.
2. Fracture of ribs, face, extremities and/or pelvis
3. Age between 18 and 75 years old
4. Adequate IV access
5. Able to self report and communicate pain severity
Exclusion Criteria:
1. History of allergy or hypersensitivity to any component of IV Ibuprofen, aspirin (or
aspirin related products) NSAIDs, or COX-2 inhibitors
2. Any intracranial or spinal cord trauma
3. History of clinically significant bleeding disorders including ITP, DIC or platelet
dysfunction
4. Recent history of intracranial surgery or stroke (within past 30 days)
5. History of ulcers, gastritis or previous GI bleeding
6. Renal Impairment (Creatinine > 3.0 mg/dL)
7. Pregnant or breastfeeding
8. Otherwise unsuitable in the opinion of the treating physician at time of
randomization.
We found this trial at
1
site
Delray Beach, Florida 33431
Principal Investigator: Russell Weisz, MD
Phone: 561-496-6622
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