A Study to Evaluate the Effects of JNJ-54861911 on Electrocardiogram Intervals in Healthy Particiants

This is a Phase 1, double blind (a medical research study in which neither the researchers
nor the participants know what treatment the participants is receiving), randomized (study
drug assigned by chance), placebo and positive-controlled, multiple-dose, 4-way crossover
(method used to switch participants from one study group to another) study. The study
consists of 3 parts: Screening period (Days -21 to -2), Double-blind treatment period and
End-of-study/early withdrawal assessment period (9 to 13 days after last dose). Treatment
period will comprise of 4 treatment regimens each consisting of a baseline assessment and a
treatment regime (Days -1 to 9). The participants will be randomly assigned to 1 of 4
treatment sequence groups (ADBC, BACD, CBDA, and DCAB) based on a computer-generated
randomization schedule and will receive the following 4 treatments in the order specified by
the randomization: Treatment A (JNJ-54861911, 50 milligram (mg) once daily for 7 days plus
moxifloxacin-matched placebo on Day 7); Treatment B (JNJ-54861911, 150 mg once daily for 7
days plus moxifloxacin-matched placebo on Day 7); Treatment C (JNJ-54861911-matched placebo
once daily for 7 days plus moxifloxacin-matched placebo on Day 7); Treatment D
(JNJ-54861911-matched placebo once daily for 7 days plus moxifloxacin 400 mg on Day 7).
Each treatment period will be separated by a washout period of at least 6 - 10 days. Total
duration of study for a participant will be 93 days. Change from Baseline in QT/QTc
intervals at Day 7 will be evaluated as primary end point. Participant's safety will be
monitored throughout the study.

Inclusion Criteria:

- Signed an informed consent document indicating they understand the purpose of and
procedures required for the study, including the required pharmacogenomics component
(which specifies testing of genes predisposing to long or short QT and related
cardiac syndromes), and are willing to participate in the study

- If a woman, must be either a) Not of childbearing potential: postmenopausal (greater
than [>] 45 years of age with amenorrhea for at least 2 years, or any age with
amenorrhea for at least 6 months and a serum follicle stimulating hormone [FSH] >40
international units per milliliter [IU/mL])or surgically sterile; b) Of child-bearing
potential and be practicing an effective method of birth control

- If a man, who is sexually active with a woman of child-bearing potential and has not
had a vasectomy, must agree to use an adequate contraception method as deemed
appropriate by the investigator

- An average of triplicate 12-lead electrocardiogram (ECG) recordings, completed within
4 minutes total, consistent with normal cardiac conduction and function, including:
a) normal sinus rhythm with heart rate between 45 and 100 beats per minutes
(inclusive); b) QTcF interval between 350 to 450 milliseconds, inclusive; c) QRS
interval of less than (<) 110 milliseconds; d) PR interval <200 milliseconds; e) PR
interval <200 milliseconds; f) ECG morphology consistent with healthy cardiac
conduction and function

- Blood pressure (after the participants remains supine for 5 minutes) between 90 and
140 milimeters of mercury (mmHg) systolic, inclusive, and no higher than 90 mmHg
diastolic

Exclusion Criteria:

- History of or current clinically significant medical illness including (but not
limited to) cardiac arrhythmias or other cardiac disease, hematologic disease,
coagulation disorders (including any abnormal bleeding or blood dyscrasias), lipid
abnormalities, significant pulmonary disease, including bronchospastic respiratory
disease, diabetes mellitus, renal or hepatic insufficiency, thyroid disease,
neurologic or psychiatric disease, infection, gastro-intestinal disease, or any other
illness that the investigator considers should exclude the parrticipants or that
could interfere with the interpretation of the study results

- History of additional risk factors for torsade de pointes or the presence of a family
history of Short QT Syndrome, Long QT Syndrome, abnormal bleeding or blood clotting,
sudden unexplained death at a young age (less than/equal to 40 years), drowning or
sudden infant death syndrome in a first degree relative (that is, biological parent,
sibling, or child)

- Use of any prescription medication (with the exception of hormonal contraceptives or
hormonal replacement therapy) within 14 days before Day -1 of Period 1; use of
nonprescription medication (including vitamins and herbal supplements such as St.
John's Wort) except for acetaminophen, within 30 days before Day -1 of Period 1;
acetaminophen within 3 days of study drug administration in each treatment period

- Clinically significant abnormal values for hematology, clinical chemistry (including
hypo- or hyperkalemia, -magnesemia, or -calcemia) or urinalysis at Screening or at
admission to the study center for Period 1 as deemed appropriate by the Investigator

- Clinically significant abnormal physical examination, vital signs or 12-lead ECG at
Screening or at admission to the study center for Period 1 as deemed appropriate by
the Investigator