BYL719 in Combination With Gemcitabine and (Nab)-Paclitaxel in Locally Advanced and Metastatic Pancreatic Cancer

Inclusion Criteria:

- Patient is able to swallow and retain oral medication

- Histologically documented diagnosis of pancreatic adenocarcinoma.

- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2

- Required baseline laboratory status according to protocol document

Exclusion Criteria:

- Prior sensitivity or intolerance to PI3K inhibitors

- Potential participants with central nervous system (CNS) involvement may participate
if the patient is: >/= 4 weeks from prior therapy completion (including radiation
and/or surgery) to starting the study treatment; Clinically stable with respect to the
CNS tumor at the time of screening; Not receiving steroid therapy.

- Prior treatment with any cytotoxic chemotherapy for treatment of pancreatic cancer
except as an adjuvant therapy. Should not have received gemcitabine within 6 months of
starting the study treatment. 5-Fluorouracil or radiation treatment should be received
more than 4 weeks prior to receiving the study drug.

- Potential participants who have received radiotherapy ≤ 4 weeks prior to starting
study drugs, with exception of palliative radiotherapy, who have not recovered from
side effects of such therapy to baseline or Grade ≤ 1 and/or from whom ≥ 30% of the
bone marrow was irradiated.

- Potential participants who have undergone major surgery ≤ 4 weeks prior to starting
study treatment or who have not recovered from side effects of such procedure.

- Have received investigation agent within 30 days prior to enrollment

- Clinically significant cardiac disease or impaired cardiac function

- QT interval adjusted according to Fredericia (QTcF) > 480 msec on screening ECG

- Potential participants with diabetes mellitus requiring insulin treatment and/or with
clinical signs or with fasting plasma glucose (FPG)> 140 mg/dL or history of
documented steroid-induced diabetes mellitus.

- Any other condition that would, in the Investigator's judgment, preclude participation
in the clinical study due to safety concerns or compliance with clinical study
procedures, e.g. infection/inflammation, intestinal obstruction, unable to swallow
oral medication, social/psychological complications.

- Impaired GI function or GI disease that may significantly alter the absorption of oral
BYL719 (e.g. ulcerative disease, uncontrolled nausea, vomiting, diarrhea,
malabsorption syndrome, or small bowel resection).

- Liver disease such as cirrhosis, decompensated liver disease, and chronic hepatitis
(i.e. quantifiable hepatitis B virus [HBV]-DNA and/or positive HbsAg, quantifiable
hepatitis C virus [HCV]-RNA).

- Known positive serology for human immunodeficiency virus (HIV)

- Known severely impaired lung function (spirometry and diffusing capacity of lung for
carbon monoxide[DLCO] 50% or less of normal and O2 saturation 88% or less at rest on
room air).

- Currently receiving warfarin or other coumarin derived anti-coagulant, for treatment,
prophylaxis or otherwise. Therapy with heparin, low molecular weight heparin (LMWH),
or fondaparinux is allowed

- Currently receiving treatment with drugs known to be strong inhibitors or inducers of
isoenzyme CYP3A. Must have discontinued strong inducers for at least one week and must
have discontinued strong inhibitors before the start of treatment. Switching to a
different medication prior to starting study treatment is allowed.

- Has a history of non-compliance to medical regimen or inability to grant consent

- Currently receiving medication with a known risk of prolonging the QT interval or
inducing Torsades de Pointes (TdP) and the treatment cannot either be discontinued or
switched to a different medication prior to starting study drug treatment

- History of another malignancy requiring active treatment within 2 years prior to
starting study treatment, except cured basal cell carcinoma of the skin or excised
carcinoma in situ of the cervix.

- Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
female after conception and until the termination of gestation, confirmed by a
positive human chorionic gonadotropin (hCG) laboratory test (> 5 mIU/mL)

- Participant who does not apply highly effective contraception during the study and
through 12 weeks after final dose of study treatment