Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
| Status: | Recruiting |
|---|---|
| Conditions: | Alzheimer Disease, Cognitive Studies |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 50 - 88 |
| Updated: | 3/13/2019 |
| Start Date: | December 1, 2014 |
| End Date: | December 31, 2019 |
| Contact: | Benjamin M Hampstead, PhD |
| Email: | bhampste@med.umich.edu |
| Phone: | (404) 321-6111 |
The aging US population threatens to overwhelm our healthcare infrastructure, especially
since the rate of Alzheimer's disease (AD) alone is expected to triple in the coming decades.
Memory cause functional impairment, reduced quality of life, increased caregiver burnout, and
eventual institutionalization. The diagnosis of mild cognitive impairment (MCI) identifies
those with memory deficits but who remain relatively independent in everyday life. MCI
provides a window for interventions that target memory functioning. The proposed study
focuses specifically on a groundbreaking combination of mnemonic rehabilitation and
non-invasive brain stimulation. The main idea is that brain stimulation can enhance
functioning in the specific brain regions/networks, thereby increasing the patients' ability
to benefit from different types of memory rehabilitation. This will be a randomized,
double-blind study (active vs. fake brain stimulation), that provides multiple treatment
session. Outcome will be examined using both laboratory-based and real-world memory testing
as well as brain imaging. This first-of-its-kind study has the potential to meaningfully
translate more "basic" science findings into neuroanatomically targeted and functionally
meaningful treatments for our aging population.
since the rate of Alzheimer's disease (AD) alone is expected to triple in the coming decades.
Memory cause functional impairment, reduced quality of life, increased caregiver burnout, and
eventual institutionalization. The diagnosis of mild cognitive impairment (MCI) identifies
those with memory deficits but who remain relatively independent in everyday life. MCI
provides a window for interventions that target memory functioning. The proposed study
focuses specifically on a groundbreaking combination of mnemonic rehabilitation and
non-invasive brain stimulation. The main idea is that brain stimulation can enhance
functioning in the specific brain regions/networks, thereby increasing the patients' ability
to benefit from different types of memory rehabilitation. This will be a randomized,
double-blind study (active vs. fake brain stimulation), that provides multiple treatment
session. Outcome will be examined using both laboratory-based and real-world memory testing
as well as brain imaging. This first-of-its-kind study has the potential to meaningfully
translate more "basic" science findings into neuroanatomically targeted and functionally
meaningful treatments for our aging population.
The proposed study focuses specifically on a groundbreaking combination of mnemonic
rehabilitation and non-invasive brain stimulation. The main idea is that brain stimulation
can enhance functioning in the specific brain regions/networks, thereby increasing the
patients' ability to benefit from memory rehabilitation. This will be a randomized,
double-blind study (active vs. fake brain stimulation), that provides multiple treatment
session. Outcome will be examined using both laboratory-based and real-world memory testing
as well as brain imaging. This first-of-its-kind study has the potential to meaningfully
translate more "basic" science findings into neuroanatomically targeted and functionally
meaningful treatments for our aging population.
The general purpose of this study is to examine the effects of two types of treatments for
memory impairment in those with mild cognitive impairment (MCI). One form of treatment is
cognitive rehabilitation, which involves teaching new ways to learn and remember information.
The second form of treatment uses a type of electrical brain stimulation called transcranial
direct current stimulation (tDCS) to increase activity in certain brain areas that may be
involved with memory. We will use brain imaging to see whether these treatments changed how
individuals learn and remember information. We will also use cognitive tests and
questionnaires to examine whether memory (and related abilities) changed because of
treatment.
rehabilitation and non-invasive brain stimulation. The main idea is that brain stimulation
can enhance functioning in the specific brain regions/networks, thereby increasing the
patients' ability to benefit from memory rehabilitation. This will be a randomized,
double-blind study (active vs. fake brain stimulation), that provides multiple treatment
session. Outcome will be examined using both laboratory-based and real-world memory testing
as well as brain imaging. This first-of-its-kind study has the potential to meaningfully
translate more "basic" science findings into neuroanatomically targeted and functionally
meaningful treatments for our aging population.
The general purpose of this study is to examine the effects of two types of treatments for
memory impairment in those with mild cognitive impairment (MCI). One form of treatment is
cognitive rehabilitation, which involves teaching new ways to learn and remember information.
The second form of treatment uses a type of electrical brain stimulation called transcranial
direct current stimulation (tDCS) to increase activity in certain brain areas that may be
involved with memory. We will use brain imaging to see whether these treatments changed how
individuals learn and remember information. We will also use cognitive tests and
questionnaires to examine whether memory (and related abilities) changed because of
treatment.
Inclusion Criteria:
General inclusion criteria (all patients):
- All medications stable for approximately 2-3 months;
- No history of severe mental illness;
- No current untreated alcohol or substance abuse/dependence;
- English as native and preferred language;
- MRI-compatible if taking part in fMRI studies
- Able to give informed consent.
MCI Inclusion Criteria:
- Diagnosis of amnestic MCI based on criteria set forth by Petersen (2004). Additionally,
other potential causes of cognitive deficit ruled out by the referring physician
Exclusion Criteria:
- History of neurological disease or injury
- History of severe mental illness
- Current untreated alcohol or substance abuse
- Other conditions may exclude; please discuss with contact
We found this trial at
1
site
Ann Arbor, Michigan 48113
Principal Investigator: Benjamin M. Hampstead, PhD
Phone: 404-321-6111
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