The Dose-Response Relationship of Rocuronium in Patients Taking Pyridostigmine
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 4/21/2016 |
| Start Date: | March 2014 |
| End Date: | September 2016 |
| Contact: | Shashi Bhatt, MD |
| Email: | shashi.bhatt@utoledo.edu |
| Phone: | 419-383-3556 |
The Dose-response Relationship of Rocuronium in Patients Taking Pyridostigmine Preoperatively Compared With Age and Sex Matched Controls
Pyridostigmine is a medication that is used in certain heart rate and blood pressure
conditions. This medication, as a side effect, is known to also cause changes in the
junction between a nerve and muscle. The changes caused at the nerve muscle junction by
pyridostigmine could alter the effect of muscle relaxants (a medication used during surgery
and anesthesia). The investigators are conducting this study to see whether patients taking
pyridostigmine are more or less sensitive to rocuronium (a muscle relaxing medication used
during surgery).
conditions. This medication, as a side effect, is known to also cause changes in the
junction between a nerve and muscle. The changes caused at the nerve muscle junction by
pyridostigmine could alter the effect of muscle relaxants (a medication used during surgery
and anesthesia). The investigators are conducting this study to see whether patients taking
pyridostigmine are more or less sensitive to rocuronium (a muscle relaxing medication used
during surgery).
Inclusion Criteria:
- Patients who take pyridostigmine for any reason or those who are matched by age, sex
and weight to subjects taking pyridostigmine
- Patients who will be administered rocuronium during elective procedures as standard
clinical care.
Exclusion Criteria:
- Allergy to rocuronium
- Known neuromuscular disorder, patients suffering from myasthenia gravis
- Subjects taking medications known to impact neuromuscular transmission (ex.
gentamicin).
We found this trial at
1
site
Toledo, Ohio 43699
Principal Investigator: Shashi Bhatt, MD
Phone: 419-383-3556
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