Liver and Fat Regulation in Overweight Adolescent Girls
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss, Obesity Weight Loss, Women's Studies, Gastrointestinal |
| Therapuetic Areas: | Endocrinology, Gastroenterology, Reproductive |
| Healthy: | No |
| Age Range: | 12 - 21 |
| Updated: | 6/30/2018 |
| Start Date: | August 2014 |
| End Date: | December 2018 |
| Contact: | Melanie Cree-Green, MD, PhD |
| Email: | melanie.green@childrenscolorado.org |
| Phone: | 720-777-6128 |
Assessment of Hepatic Glucose and Fat Regulation in Overweight Adolescent Girls
Women with polycystic ovarian syndrome (PCOS) have increased rates of hepatic steatosis
compared to weight similar women with regular menses. It is unclear if this is related to
high testosterone or insulin resistance. The investigators will assess hepatic glucose
release, rates of lipolysis and hepatic de novo lipogenesis in the fasted and postprandial
state to determine if alterations in the processes contribute to hepatic steatosis. Subjects
will be overweight, sedentary girls with or without PCOS who are not receiving medical
therapy for insulin resistance, or PCOS.
compared to weight similar women with regular menses. It is unclear if this is related to
high testosterone or insulin resistance. The investigators will assess hepatic glucose
release, rates of lipolysis and hepatic de novo lipogenesis in the fasted and postprandial
state to determine if alterations in the processes contribute to hepatic steatosis. Subjects
will be overweight, sedentary girls with or without PCOS who are not receiving medical
therapy for insulin resistance, or PCOS.
Hepatic glucose release will be assessed with a stable isotope glycerol tracer, lipolysis
with a glycerol tracer, and hepatic de novo lipogenesis with an acetate tracer. Data will be
collected fasting and after a glucose challenge. The degree of hepatic steatosis and
abdominal fat partitioning will be assessed with Magnetic Resonance Imaging (MRI), and total
body composition with Dual-energy X-ray absorptiometry (DEXA).
with a glycerol tracer, and hepatic de novo lipogenesis with an acetate tracer. Data will be
collected fasting and after a glucose challenge. The degree of hepatic steatosis and
abdominal fat partitioning will be assessed with Magnetic Resonance Imaging (MRI), and total
body composition with Dual-energy X-ray absorptiometry (DEXA).
Inclusion Criteria:
- Females
- 2 years post-menarche
- BMI percentile >90%
Exclusion Criteria:
- Type 2 diabetes
- Anemia
- Liver disease
- Medications known to effect insulin sensitivity
- Cause of oligomenorrhea or hirsutism other than PCOS,
- >3 hours a week of moderate exercise.
We found this trial at
1
site
Aurora, Colorado 80045
Phone: 720-777-6984
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