Telemedici ne Management of Veterans With Newly Diagnosed Obstructiv e Sleep Apnea (OSA)

Obstructive sleep apnea is a high-priority clinical condition for the Veterans Health
Administration. With approximately 2% of middle-aged women and 4% of middle-aged men having
OSA, the disorder places significant burden on the healthcare system. Obstructive sleep
apnea (OSA) has been linked to major cardiovascular disorders such as coronary artery
disease, congestive heart failure, hypertension, and stroke, as well as increased risk for
motor vehicle crashes. Positive airway pressure (PAP) therapy is considered the treatment of
choice for obstructive sleep apnea. However, adherence rates with CPAP and APAP therapy are
disappointingly low. Veterans, especially those who are socioeconomically disadvantaged and
those with psychiatric disease, demonstrate poor adherence when compared to the general
population. Effective interventions are needed to improve adherence among patients diagnosed
with OSA.

Currently, veterans diagnosed with OSA at the Philadelphia VA sleep center are treated with
a home APAP machine that records their adherence on a smart card. They are scheduled for a
follow-up appointment within one to three months after their initiation of APAP therapy to
discuss questions and concerns regarding the machine as well as the mask and to download
their adherence data. Given the limited availability of clinic appointments, some patients
may have to wait longer than this.

More recently, APAP machines now distributed through the VA system offer the possibility of
using wireless transmissions to track adherence data, including hours of use, mask leak, and
apnea-hypopnea index (this transmission does not require hook up to the telephone and does
not require the patient to have internet access). This offers the opportunity to see if
remote monitoring within the first several weeks of APAP treatment improves adherence, and
in turn, improves clinical response to treatment. At the present time, all patients enrolled
at Philadelphia Veterans Administration Medical Center (PVAMC) who are newly diagnosed with
OSA are being provided with APAP machines with modems that allow for wireless transmissions
of data through the Phillips Respironics HIPPA compliant website, www.encoreanywhere.com.
Review of the modem data is being performed on a limited basis in some patients. If remote
monitoring improves adherence, the investigators may want to implement it for all APAP
users. At present, the investigators do not know if this is a clinically effective or cost
effective model for delivering health care.

The investigators will have a baseline chart review. It will include assessment of APAP
settings (auto-titrate pressure ranges), model and size of mask interface, baseline sleep
study results (mean AHI), and review of surveys now obtained as part of routine clinical
care at the investigators sleep center, including: Epworth Sleepiness Scale (ESS) score,
functional outcomes of sleep questionnaire (FOSQ) score, center for epidemiological studies
of depression scale (CES-D score), short form health survey (SF-12), a health survey score
and client satisfaction questionnaire (CSQ-8).

Sleep center staff will also perform a chart review to obtain demographic information (age,
sex, race), BMI, daytime oxygen saturation (if available), and co-morbidities (congestive
heart failure, diabetes, hypertension, obesity, chronic obstructive pulmonary disease
(COPD), and depression or other psychological disorders) as part of their problem list in
the computerized VA medical record. the investigators will use this chart review to compute
a Charlson Morbidity Index.

The investigators then plan to randomize 126 patients to either usual care or usual care in
addition to telemonitoring.

Standard of Care Arm: Patients assigned to receive standard of care will be set-up with an
APAP machine through Eagle Home Medical, our contracted local home health care agency.
Patients will also receive the sleep staff's phone number should they encounter problems
with the use of their new equipment. Patients will be scheduled to see a sleep practitioner
within one to three months of the initiation of APAP therapy.

At the follow-up office visit, practitioners will assess mask leak, mean daily APAP usage,
AHI through either secure digital (SD) cards or Encore Anywhere. Practitioners will also
calculate the patient's ESS score and inquire about frequent complications associated with
APAP-usage, such as dry mouth and mask discomfort.

After three months of treatment, all patients in the usual care arm will also have their
EncoreAnywhere data reviewed. They will receive a phone call from our sleep center staff to
assess their experience with their APAP machines. If patients have not had a follow-up
clinic visit, they will be scheduled for one. In addition, all subjects will be mailed
survey to reassess their functional outcomes including: ESS score, FOSQ- 10, another
subjective measurement of sleepiness, the CES-D score, an assessment of depression symptoms,
the CSQ-8, an assessment of patient satisfaction, and the SF-12 health survey, an assessment
of health.

Telemonitoring Arm: Patients will be set-up with an APAP machine through Eagle Home Medical,
our contracted local home health care agency. Patients will also receive the sleep staff's
phone number should they encounter problems with the use of their new equipment. Patients
will be scheduled to see a sleep practitioner within one to three months of the initiation
of APAP therapy. At that follow-up appointment, APAP settings, APAP adherence, mask comfort,
humidifier usage, and ESS score will be assessed.

In addition, patients in the telemonitoring arm will have their adherence data monitored by
sleep research staff. Patients who demonstrate poor adherence will receive phone calls at
scheduled intervals (Day 2, Day 9, and Day 16). Poor adherence is defined as a large mask
leak for 30% of the night, 30% or more of days with less than 4 hours of use, or an AHI > 10
events/hr.

Day 2 (Can call up to 120 hours after initiation of treatment) Two days after initiation of
APAP data, intervention arm patients will have their data reviewed by the sleep study staff.
Patients will receive a follow-up call if any of the following are present: large mask leak,
30% or more of days with less than 4 hours of use, or machine measured average AHI > 10
events/hr. Patients will be assessed for symptoms such as dry mouth, mask issues, or
discomfort with the device, or any other problems. Interventions to improve adherence (i.e.:
a different mask, chin strap, modifications of pressure settings, modifications of
humidifier settings, saline nasal sprays) will then be prescribed if needed. Patients will
also be given the sleep center number if they have questions regarding the use of their
equipment.

Day 9: (Can call up to 120 hours after Day 9) Patients in the intervention arm will have
their data reviewed again. They will receive a follow-up call if poor adherence is noted.
Symptoms will be assessed and interventions to improve adherence will be offered.

Day 16: (Can call up to120 hours after Day 16) Patients in the intervention are will have
their data reviewed again and called if poor adherence and/or efficacy is noted. Symptoms
will be assessed and interventions to improve adherence will be offered.

Three Month Follow-up: All patients will have their EncoreAnywhere data reviewed. If
patients have not had a follow-up visit within one to three months of APAP set-up, they will
be scheduled for one. Surveys will be mailed to all subjects to reassess functional
outcomes, including: ESS, FOSQ, CES-D, SF-12 health survey, and CSQ-8.

Inclusion Criteria:

- Male and female veterans at least 18 years of age.

- Ability to read and speak English (assessment instruments and therapy will be
available only in English).

- AHI> 5 on baseline home sleep study

- Agree to initiate automatically titrating continuous positive airway pressure (APAP)
therapy.

- Completion of clinic questionnaires during initial sleep evaluation

Exclusion Criteria:

- Unwilling to provide informed consent.

- Lack of English fluency. This will be determined when potential subjects are
contacted by phone. If they are able to understand the oral consent by correctly
completing the mini-quiz, English fluency will be established.

- No telephone access

- Patients previously treated with positive airway pressure.

- Patients enrolled in ongoing VA sleep research studies. Currently all patients
enrolled in VA sleep research studies already have their charts flagged.

- Patients receiving their sleep care at VA medical centers other than PVAMC, Fort Dix,
Gloucester and Victor J. Saracini (Willow Grove).

- Patients initiated on positive airway pressure treatment while in-patients will also
be excluded.

- Patients who are set up with APAP machines without modems will also be excluded.