Risk of Diabetes in Young Turner Syndrome Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Other Indications |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 6 - 22 |
| Updated: | 4/21/2016 |
| Start Date: | May 2014 |
| End Date: | December 2015 |
| Contact: | Nicole Sheanon, MD |
| Email: | Nicole.Sheanon@cchmc.org |
| Phone: | 513-636-4549 |
Beta-Cell Function in Young Turner Syndrome Patients
Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome
have abnormalities in glucose metabolism which can lead to diabetes. The current screening
guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood
sugar once a year. The objective of this study is to determine if there are abnormalities in
glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study
hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin)
is more prevalent in girls with Turner Syndrome compared to healthy controls.
have abnormalities in glucose metabolism which can lead to diabetes. The current screening
guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood
sugar once a year. The objective of this study is to determine if there are abnormalities in
glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study
hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin)
is more prevalent in girls with Turner Syndrome compared to healthy controls.
The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study
will require 1 visit to the hospital where the subject will have an oral glucose tolerance
test and a physical exam
will require 1 visit to the hospital where the subject will have an oral glucose tolerance
test and a physical exam
Turner Syndrome Females:
Inclusion Criteria:
- Turner Syndrome confirmed by chromosomal testing
- On standard therapy (growth hormone and or estrogen)
Exclusion Criteria:
- Type 1 or Type 2 diabetes
- Polycystic Ovarian Syndrome
- Pregnancy
- On any medications that alter blood sugar
Healthy Female Controls:
Inclusion Criteria:
- Healthy
Exclusion Criteria:
- Type 1 or Type 2 diabetes
- Polycystic Ovarian Syndrome
- Pregnancy
- On any medications that alter blood sugar
We found this trial at
1
site
Cincinnati, Ohio 45229
Principal Investigator: Philippe Backeljauw, MD
Phone: 513-636-4549
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